Antimicrobial Therapy as a Risk Factor of Multidrug-Resistant Acinetobacter Infection in COVID-19 Patients Admitted to the Intensive Care Unit

Table 5

Multivariate analysis of association of possible risk factors with the risk of MDR-Ab isolation.

Variable	Odds ratio (95% confidence interval)	Beta
Previous ceftriaxone exposure	4.11 (1.42–11.91)	1.41	<0.05
Tocilizumab therapy	4.47 (1.33–15.03)	1.50	<0.05
Mechanical ventilation	1.80 (0.64–5.09)	0.59	0.26
ICU length of stay exceeding 11 days	3.71 (1.33–10.32)	1.31	<0.05

ICU: intensive care unit; MDR-Ab: multidrug-resistant Acinetobacter; P: probability. Associations between MDR-Ab isolation and infection and age, diabetes mellitus, ICU length of stay exceeding 11 day, mechanical ventilation, obesity, previous ceftriaxone exposure, previous meropenem exposure, tocilizumab therapy, C-reactive protein, glomerular filtration rate, neutrophil count, lymphocyte count, and CD4+ lymphocyte count were assessed using a multivariate binary logistic regression model with a forward stepwise procedure, entering all variables with in univariate analysis. Statistical significance was established at . Only variables such as ICU length of stay exceeding 11 day, mechanical ventilation, previous ceftriaxone exposure, and tocilizumab therapy were included in the final model. Other variables were excluded because they were found to be insignificant in the forward stepwise procedure.