Diagnostic Accuracy of Immunologic Biomarkers for Accurate Diagnosis of Bloodstream Infection in Patients with Malignancy: Procalcitonin in Comparison with C-Reactive Protein

Table 5

Sensitivity and specificity and PPV and NPV of CRP and PCT markers to distinguish bacteremia from nonbacteremia at optimal cutoff in comparison with standard cutoff based on ROC curve results.

Marker		Cutoff	Sensitivity (95% CI) in %	Specificity (95% CI) in %	PPV in %	NPV in %
PCT	Standard cutoff (ng/ml)	0.5	73.33 (44.9–92.2)	61.86 (55.3–68.1)	10.76	97.37
	Optimal cutoff (ng/ml)	1.17	66.67 (38.4–88.2)	80.08 (74.4–85)	17.34	97.46
CRP	Standard cutoff (mg/l)	10	100 (78.2–100)	7.63 (4.6–11.8)	6.36	100
	Optimal cutoff (mg/l)	47	86.67 (59.5–98.3)	33.05 (27.1–39.4)	7.5	97.53