Sterol Carrier Protein Inhibition-Based Control of Mosquito Vectors: Current Knowledge and Future Perspectives

Table 1

Synthetic organic compounds with AeSCP-2 inhibitory activity against Ae. aegypti [42, 43].

Compounds	(IC50/EC50) µM
SCPIs
N-(4-{[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]amino}phenyl)acetamidehydrobromide (SCPI-1)	0.347 (IC50)
8-Chloro-2-(3-methoxyphenyl)-4,4-dimethyl-4,5-dihydroisothiazolo[5,4-c]quinoline-1(2H)-thione (SCPI-2)	0.059 (IC50)
3-(4-Bromophenyl)-5-methoxy-7-nitro-4H-1,2,4-benzoxadiazine (SCPI-3)	0.159 (IC50)
4,4,8-Trimethyl-5-(3-methylbutanoyl)-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinoline-1-thione (SCPI-4)	0.065 (IC50)
3-Bromo-N-{2-[(4-chloro-2-nitrophenyl)amino]ethyl}-4-ethoxybenzamide (SCPI-5)	0.042 (IC50)
Synthetic analogs of curcumin
(2E,6E)-2-6-Bis(3,4,5-trimethoxybenzylidene) cyclohexanone	12.11 (EC50)
(2E,6E)-2-6-Bis(furan-2-ylmethylene) cyclohexanone	62.87 (EC50)
(1E,4E)-1,5-Bis(4-hydroxyphenyl) penta-1,4-dien-3-one	2.38 (EC50)
(1E,4E)-1-(2-Hydroxyphenyl)-5-phenylpenta-1,4-dien-3-one	2.02 (EC50)
1,5-Bis-(3,4,5-trimethoxy-phenyl)-penta-1,4-dien-3-one	0.65 (EC50)