Association between Elevated Serum Tau Protein Level and Sepsis-Associated Encephalopathy in Patients with Severe Sepsis

Table 2

Relative performance of serum tau protein, SOFA score, or a combination of both in predicting SAE in patients with severe sepsis.

	AUC (95% CI)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Positive LR	Negative LR
Tau protein	0.770 (0.671–0.89)	70.4	72.0	45.3	88.1	2.514	0.411
SOFA score	0.723 (0.615–0.82)	66.7	65.9	39.2	85.7	1.956	0.505
Tau protein + SOFA score	0.798 (0.705–0.890)	81.5	70.0	47.3	92.0	2.717	0.264

AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value; LR, likelihood ratio; CI, confidence interval; SOFA: Sequential Organ Failure Assessment. The diagnostic cutoff values for serum tau protein and SOFA score were 71.96 pg/mL and 6, respectively.