Research Article
Association between Elevated Serum Tau Protein Level and Sepsis-Associated Encephalopathy in Patients with Severe Sepsis
Table 1
Baseline demographic and clinical findings between the SAE and non-SAE groups.
| | Items | Total (n = 109) | SAE (n = 27) | Non-SAE (n = 82) | value |
| | Age, y, mean ± SD | 61.7 ± 13.0 | 64.4 ± 14.2 | 57.8 ± 12.5 | 0.142 |
| | Male/Female | 64/45 | 16/11 | 48/34 | 0.386 |
| | Disease severity, mean ± SD | | | | | | APACHE II score | 18.4 ± 5.2 | 21.8 ± 6.7 | 15.2 ± 4.6 | 0.013 | | SOFA score | 6.3 ± 3.1 | 8.7 ± 2.6 | 4.8 ± 3.3 | <0.001 |
| | Inflammatory markers | | | | | | WBC, mean ± SD (×109/L) | 15.24 ± 9.90 | 16.54 ± 9.67 | 13.81 ± 10.17 | 0.373 | | PCT, mean ± SD (ng/mL) | 35.24 ± 27.81 | 30.77 ± 26.32 | 38.24 ± 30.46 | 0.214 | | CRP, mean ± SD (mg/L) | 193.84 ± 91.21 | 196.92 ± 87.84 | 188.47 ± 96.45 | 0.307 |
| | Biochemistry | | | | | | Lactate, mean ± SD (mmol/L) | 3.12 ± 2.03 | 3.86 ± 2.12 | 2.40 ± 1.71 | 0.011 | | Glucose, mean ± SD (mmol/L) | 8.95 ± 3.07 | 9.35 ± 3.32 | 8.71 ± 2.69 | 0.413 | | Creatinine, mean ± SD (μmol/L) | 135.74 ± 28.61 | 142.46 ± 31.40 | 126.45 ± 26.91 | 0.092 | | BUN, mean ± SD (mmol/L) | 12.27 ± 9.76 | 13.08 ± 10.26 | 11.44 ± 9.34 | 0.194 | | Albumin, mean ± SD (g/L) | 25.06 ± 5.86 | 24.75 ± 6.28 | 26.35 ± 5.32 | 0.316 | | Total bilirubin, mean ± SD (mmol/L) | 22.31 ± 5.82 | 24.52 ± 6.33 | 21.41 ± 5.06 | 0.481 | | AST, median (range) (U/L) | 346 (43–12016) | 395 (48–12016) | 320 (43–9830) | 0.106 | | ALT, median (range) (U/L) | 156 (25–8900) | 172 (25–8900) | 142 (34–7500) | 0.085 | | Cholesterol, mean ± SD (mmol/L) | 3.44 ± 0.47 | 2.78 ± 0.42 | 4.01 ± 0.50 | 0.126 | | BNP, median (range) (pg/mL) | 1710 (520–12800) | 1740 (570–12800) | 1630 (520–9200) | 0.124 | | pH, mean ± SD | 7.40 ± 0.11 | 7.39 ± 0.09 | 7.40 ± 0.13 | 0.437 | | PaO2, mean ± SD (mmHg) | 77.26 ± 43.21 | 78.32 ± 44.85 | 76.37 ± 42.09 | 0.753 | | PaCO2, mean ± SD (mmHg) | 43.02 ± 19.43 | 42.65 ± 18.44 | 44.69 ± 20.79 | 0.321 | | HCO3−, mean ± SD (mmol/L) | 24.01 ± 4.05 | 25.62 ± 4.21 | 23.18 ± 3.50 | 0.416 |
| | Infection sites | | | | 0.473 | | Respiratory system | 39 (35.8) | 9 (33.3) | 30 (36.6) | | | Urinary system | 32 (29.4) | 6 (22.3) | 26 (31.7) | | | Blood | 17 (15.6) | 5 (18.5) | 12 (14.6) | | | Digestive system | 12 (11.0) | 4 (14.8) | 8 (9.8) | | | Skin or soft tissue | 6 (5.5) | 2 (7.4) | 4 (4.9) | | | Other | 3 (2.7) | 1 (3.7) | 2 (2.4) | |
| | Bacteriological categories | | | | 0.228 | | Gram-negative bacteria | 70 (64.2) | 16 (59.3) | 54 (65.9) | | | Gram-positive bacteria | 35 (32.1) | 9 (33.3) | 26 (31.7) | | | Fungi | 4 (3.7) | 2 (7.4) | 2 (2.4) | | | Mechanical ventilation days | 6.5 ± 7.6 | 8.6 ± 10.8 | 3.1 ± 5.2 | 0.017 | | Days in the ICU | 9.3 ± 12.7 | 11.5 ± 16.2 | 7.7 ± 8.2 | 0.023 | | 28-day mortality | 33.0% | 51.9% | 26.8% | 0.016 |
|
|
APACHE: Acute Physiology and Chronic Health Evaluation; SOFA: Sequential Organ Failure Assessment; WBC: white blood cells; PCT: procalcitonin; CRP: C-reactive protein; BUN: blood urea nitrogen; AST: aspartate aminotransferase; ALT: alanine aminotransferase; BNP: B-type natriuretic peptide. . |
