Plexin C1 Marks Liver Cancer Cells with Epithelial Phenotype and Is Overexpressed in Hepatocellular Carcinoma

Figure 1

In silico analyses of PLXNC1 expression. (a) Chen Liver microarray data compares the expression of 10802 genes between 104 HCC and 76 normal liver tissues. The mean of PLXNC1 mRNA levels in HCCs is 2.77 fold higher than the mean of normal tissues. (b) Segregation of HCC cell lines with respect to their epithelial versus mesenchymal characteristics is analyzed on “EMBL-EBI Expression Atlas” database through the transcript levels of PLXNC1, CDH1, PRKCA, and VIM in HCC cells. HCC cells with epithelial phenotype include PLC/PRF/5, HEP3B, HUH7, and HUH6. HCC cell lines with mesenchymal phenotype are SNU398, SNU1079, SNU878, SNU886, SNU387, JHH2, HLF, SNU423, SK-HEP1, and SNU449.

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