Macroscopic Portal Vein Thrombosis in HCC Patients

Table 1

Comparisons amongst HCC patients between portal vein thrombosis groups, in single MTD categories.

	MTD<5.0 (cm)			5.0≤MTD≤10.0 (cm)			MTD>10.0 (cm)
Parameter	PVT(No)	PVT(Yes)		PVT(No)	PVT(Yes)		PVT(No)	PVT(Yes)
	(n=701)	(n=112) (13.7%)		(n=388)	(n=199) (33.9%)		(n=84)	(n=109) (56.4%)
Sex (M) (%)	145 (79.32)	88 (78.57)	0.86^∧	319 (82.22)	164 (82.41)	0.95^∧	72 (85.71)	96 (88.07)	0.63^∧
Age (yr)	61.55±11.04	61.59±11.53	0.98	63.86±10.95	61.24±11.88	0.005	63.89±12.52	60.69±13.68	0.08
Cigarettes smoke (%)	159 (44.04)	32 (42.11)	0.76^∧	129 (60.85)	79 (56.03)	0.37^∧	26 (55.32)	32 (57.14)	0.85^∧
Alcohol (%)	63 (17.65)	8 (11.11)	0.17^∧	27 (13.85)	25 (18.12)	0.29^∧	7 (20.00)	7 (12.07)	0.30^∧
Child-Pugh (B&C)			0.01 ^∧			<0.001^∧			0.47 ^∧
A	217 (39.19)	18 (22.22)		138 (44.23)	44 (26.04)		26 (35.14)	23 (26.44)
B	212 (38.27)	41 (50.62)		118 (37.82)	70 (41.42)		28 (37.84)	39 (44.83)
C	125 (22.56)	22 (27.16)		56 (17.95)	55 (32.54)		20 (27.03)	25 (28.74)
Cirrhosis (%)	542 (79.47)	88 (87.13)	0.07 ^∧	301 (77.98)	168 (85.71)	0.03^∧	62 (73.81)	81 (77.88)	0.51 ^∧
Albumin (g/dL)	3.15±0.76	2.95±0.76	0.02	3.11±0.75	2.97±0.71	0.07	3.04±0.74	3.00±0.63	0.60
GGTP (U/L)	148.07±186.14	143.42±134.30	0.41	147.47±153.36	210.61±206.48	0.0003	186.06±153.04	213.74±175.12	0.34
AST (U/L)	118.06±226.07	102.20±92.59	0.86	100.88±121.40	114.37±105.87	0.02	146.35±425.67	114.46±112.63	0.07
ALKP (U/L)	190.97±216.09	191.34±168.76	0.40	193.97±139.92	279.19±313.31	0.02	232.77±149.04	268.86±241.38	0.96
Bilirubin (mg/dL)	2.41±3.45	2.52±3.41	0.67	2.27±3.67	3.60±5.44	0.009	1.96±3.06	2.58±3.61	0.22
Platelet counts (10^3/μL)	139.16±85.58	141.80±90.29	0.92	161.86±89.36	180.04±108.38	0.10	226.94±141.19	227.79±127.74	0.63
AFP (IU/mL)	1774.84±13163.19	2722.60±8062.90	<0.0001	3504.43±18586.15	10976.9±54278.4	0.0007	9395.0±29325.7	18393.3±55766.2	0.02
MTD (cm)	2.91±1.01	3.13±0.94	0.03	7.00±1.73	7.47±1.66	0.0004	14.29±3.56	14.24±3.17	0.91
Nodules number (%)			0.002 ^∧			<0.001^∧			<0.001^∧
Unifocal	507 (72.53)	62 (57.94)		271 (70.76)	98 (50.52)		67 (79.76)	55 (55.00)
Multifocality (≥2)	192 (27.47)	45 (42.06)		112 (29.24)	96 (49.48)		17 (20.24)	45 (45.00)

All values: means ± standard deviation as continuous; Frequencies and percentage (%) as categorical.
Wilcoxon rank-sum (Mann–Whitney) test; ^∧ Chi-square test.
GGTP, gamma glutamyl transpeptidase; ALKP, alkaline phosphatase; AFP, alpha-fetoprotein; MTD, maximum tumor diameter; PVT, portal vein thrombosis.