Prognostic Impact of Cirrhosis in Patients with Intrahepatic Cholangiocarcinoma following Hepatic Resection

Table 3

Univariate and multivariate analysis of variables that significantly affected the survival outcomes.

Variables	Overall survival					Relapse-free survival
	Univariate analysis			Multivariate analysis		Univariate analysis			Multivariate analysis
	1 yr	5 yr	value	HR (95% CI)	value	1 yr	5 yr	value	HR (95% CI)	value
HBsAg
Positive	70.0	25.0	0.025	0.665 (0.363–1.220)	0.188	63.3	25.0	0.002	0.505 (0.279–0.914)	0.024
Negative	48.7	6.8				30.3	6.3
Tumor size
>5 cm	44.3	5.9	0.002	1.923 (1.147–3.226)	0.013	26.2	5.7	0.003	1.947 (1.177–3.219)	0.009
≤5 cm	68.9	21.4				57.8	19.4
Child-Pugh score
A	56.0	12.3	0.005	3.349 (1.387–8.090)	0.007	41.0	11.5	0.017	3.067 (1.293–7.275)	0.011
B	33.3	0				16.7	0
Vascular invasion
Present	39.3	4.3	0.049	1.867 (1.103–3.159)	0.020			NS
Absent	60.3	14.3
Lymph node metastasis
Present	37.5	0	<0.001	2.790 (1.628–4.781)	<0.001	18.8	0	<0.001	2.188 (1.310–3.654)	0.003
Absent	69.0	25.0				56.9	22.5
Tumor number
Single			NS			43.8	13.2	0.046	1.150 (0.638–2.071)	0.643
Multiple						17.6	0

HR, hazard ratio; CI, confidence interval; HBsAg, hepatitis B surface antigen; NS, not significant.