Modern Treatments and Stem Cell Therapies for Perianal Crohn’s Fistulas

Table 2

Published and ongoing clinical trials using MSCs for the treatment of Crohn’s perianal fistula.

Authors/trial code	Study design	Status and results
García-Olmo et al. 2005 [59]	(phase I study); Autologous adipose derived stem cells	Trial completed; 75% of fistulas have complete closure at week 8
Garcia-Olmo et al. 2009 [60]	(phase II study); Autologous adipose derived stem cells + fibrin glue	Trial completed; Fistula healing: 71% versus 16%
Ciccocioppo et al. 2011 [58]	(prospective study); Autologous mesenchymal stem cells	Reduction in Crohn’s disease activity index and pain/discharge scores
Herreros et al. 2012 [61]; NCT00475410	(phase III study); Autologous adipose derived stem cells + fibrin glue	Trial completed; At 1 year, the healing rates were 57.1% (stem cells alone), 52.4% (stem cells + fibrin glue), and 37.3% (fibrin glue alone)
Molendijk et al. 2015 [64]; NCT01144962	(phase II study); Allogeneic adipose derived stem cells; Placebo-control	Trial completed; Healing up to 85%
Panés et al. 2016 [62]; NCT01541579	(Phase III study); Allogeneic adipose derived stem cells versus placebo	Trial ongoing; 50% versus 34% achieved combined remission
NCT01915927	(Phase I study); Autologous adipose derived stem cells coated fistula plug	Trial recruiting patients