Current Gerontology and Geriatrics Research

Aging and Down Syndrome


Publishing date
01 Apr 2012
Status
Published
Submission deadline
01 Oct 2011

Lead Editor

1Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA

2Department of Pediatrics and Neurology, MIND, University of California, Irvine, CA 92697, USA

3Intellectual Disabilities Research, Department of Behavioral Psychology, Kennedy Krieger Institute, Baltimore, MD 21205, USA

4Eleanor Roosevelt Institute, University of Denver, Denver, CO 80208, USA


Aging and Down Syndrome

Description

Down syndrome or trisomy 21 is one of the most common causes of intellectual disability, with recent national incidence estimates suggesting that 1 per 691 live births have DS (or over 5000 DS births annually). DS is associated with characteristic facial features, deficits in the immune and endocrine systems as well as delayed cognitive development. Improvements in medical care for children and adults with DS have led to significant extensions in lifespan and enhanced quality of life. However, virtually all adults with DS develop neuropathology consistent with a diagnosis of Alzheimer disease (AD) by the age of 40 years, including β-amyloid (Aβ) plaques and neurofibrillary tangles. Thus, a key challenge to adults with DS as they age is the increasing risk for developing dementia, yet our social and medical infrastructure is not as well prepared for providing care to adults with DS as they age relative to the outstanding support available to families and children with DS. This special issue will address a breadth of relevant issues defining the concerns faced by adults with Down syndrome as they grow older and the systems of supports and services needed to address those concerns.

We invite authors to submit original research and review articles that address aging in DS. We are interested in articles that discuss genetic, neurologic, cognitive, neurobiological, and social features of aging in DS. Reviews and or studies in transgenic mouse models of DS are also encouraged. Potential topics include, but are not limited to:

  • Diagnosis of dementia or mild cognitive impairment in DS
  • Changes in neurological or health status with aging or dementia in DS
  • Neuropsychological features of aging and/or dementia in DS
  • Age-related neuropathology in DS (related either to AD or other diseases, including amyloid deposition, neurofibrillary pathology, inflammation, oxidative damage, mitochondrial dysfunction, etc.)
  • Biomarkers of aging or dementia in DS (imaging, blood, CSF, other)
  • Risk factors and/or protective factors and dementia in DS
  • Genetics that lead to enhanced vulnerability with advancing age in DS
  • Aging and mouse models of DS
  • Treatment of dementia in DS
  • Ethical/social implications of aging and dementia in DS (e.g., caregiver support, end-of-life decisions)
  • Systems of support for promoting successful aging and maximizing quality of life for older adults with DS

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/cggr/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 412536
  • - Editorial

Aging and Down Syndrome

Elizabeth Head | Wayne Silverman | ... | Ira T. Lott
  • Special Issue
  • - Volume 2012
  • - Article ID 782671
  • - Research Article

Gait Parameter Adjustments for Walking on a Treadmill at Preferred, Slower, and Faster Speeds in Older Adults with Down Syndrome

Beth A. Smith | Masayoshi Kubo | Beverly D. Ulrich
  • Special Issue
  • - Volume 2012
  • - Article ID 943890
  • - Clinical Study

Clinical Predictors of Mortality in Adults with Intellectual Disabilities with and without Down Syndrome

Lilian Thorpe | Punam Pahwa | ... | Josephine Nanson
  • Special Issue
  • - Volume 2012
  • - Article ID 179318
  • - Research Article

Sterol Lipid Metabolism in Down Syndrome Revisited: Down Syndrome Is Associated with a Selective Reduction in Serum Brassicasterol Levels

Gavin Tansley | Daniel T. Holmes | ... | Cheryl L. Wellington
  • Special Issue
  • - Volume 2012
  • - Article ID 383170
  • - Review Article

Oxidative Stress and Mitochondrial Dysfunction in Down’s Syndrome: Relevance to Aging and Dementia

Pinar E. Coskun | Jorge Busciglio
  • Special Issue
  • - Volume 2012
  • - Article ID 974253
  • - Research Article

Ophthalmic Disorders in Adults with Down Syndrome

Sharon J. Krinsky-McHale | Edmund C. Jenkins | ... | Wayne Silverman
  • Special Issue
  • - Volume 2012
  • - Article ID 463909
  • - Review Article

Age-Related Neurodegeneration and Memory Loss in Down Syndrome

Jason P. Lockrow | Ashley M. Fortress | Ann-Charlotte E. Granholm
  • Special Issue
  • - Volume 2012
  • - Article ID 361218
  • - Research Article

Polymorphisms in HSD17B1: Early Onset and Increased Risk of Alzheimer’s Disease in Women with Down Syndrome

Joseph H. Lee | Susan Gurney | ... | Nicole Schupf
  • Special Issue
  • - Volume 2012
  • - Article ID 362839
  • - Review Article

β-Secretases, Alzheimer’s Disease, and Down Syndrome

Robin L. Webb | M. Paul Murphy
  • Special Issue
  • - Volume 2012
  • - Article ID 717315
  • - Review Article

The Use of Mouse Models for Understanding the Biology of Down Syndrome and Aging

Guido N. Vacano | Nathan Duval | David Patterson
Current Gerontology and Geriatrics Research
 Journal metrics
Acceptance rate-
Submission to final decision119 days
Acceptance to publication65 days
CiteScore1.640
Impact Factor-
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