Determination of Cutoff Values for the Screening of Osteosarcopenia in Obese Postmenopausal Women

Table 5

Prevalence of OSO and its variations based on the new criteria and cutoff values (N = 141).

Criteria and cutoff values used to define OSO	OSO	OO	SO	OB	NR
	N (%)	N (%)	N (%)	N (%)	N (%)
Old
T-score ≤ −2.5	8 (5.7)	6 (4.3)	24 (17.0)	82 (58.2)	7 (5.0)
AppSMMI ≤ 5.7 kg/m^2
BFP ≥ 32%
New (Criteria 1)
BUA ≤ 52.85 dB/MHz	12 (8.5)	5 (3.5)	39 (27.7)	64 (45.4)	5 (3.5)
SMMI ≤ 8.2 kg/m^2
BFP ≥ 32%
Sensitivity (%)	100	83.33	100	78.0	71.4
Specificity (%)	97.0	100	87.0	100	100
New (Criteria 2)
BUA ≤ 52.85 dB/MHz	7 (5.0)	10 (7.1)	29 (20.6)	74 (52.5)	5 (3.5)
FFMI ≤ 15.2 kg/m^2
BFP ≥ 32%
Sensitivity (%)	87.5	100	100	90.2	71.4
Specificity (%)	100	97.0	95.7	100	100
New (Criteria 3)
BUA ≤ 52.85 dB/MHz	5 (3.5)	3 (2.1)	15 (10.6)	46 (32.6)	4 (2.8)
SMMI ≤ 8.2 kg/m^2
HGS ≤ 16.5 kg
BFP ≥ 32%
Sensitivity (%)	62.5	50.0	62.5	56.1	57.1
Specificity (%)	100	100	100	100	100

The sensitivity (Sn) is defined as the probability of a positive test in a diseased person (Sn = true positive ÷ true positive/false negative). The specificity (Sp) is defined as the likelihood of a negative test in a person without the disease (Sp = true negative ÷ true negative/false positive). Fourteen participants (n = 14, 10%) are normal weight with either sarcopenic or osteopenic/osteoporotic. OSO: osteosarcopenic obesity; OO: osteopenic obesity; SO: sarcopenia obesity; OB: obese-only; NR: healthy, normal weight; appSMMI: appendicular skeletal muscle mass index; SMMI: skeletal muscle mass index; FFMI: fat-free muscle mass index; BUA: broadband ultrasonic attenuation; BFP: body fat percent; HGS: handgrip strength.