| Combinations of diseases | By sex | Females | Males |
| Four diseasesa | HR | (95% CI) | HR | (95% CI) | HT-CD-MSDs-DM | 1.74 | 0.95, 3.19 | 5.72 | 1.72, 19.06 | Three of four | 2.40 | 1.66, 3.48 | 1.83 | 1.21, 2.73 | Two of four | 1.50 | 1.15, 1.95 | 1.45 | 1.06, 2.00 | One of four | 1.46 | 1.17, 1.81 | 1.24 | 0.98, 1.55 | HT-CD-MSDs-MD | 2.16 | 1.04, 4.51 | 3.81 | 2.04, 7.08 | Three of four | 1.91 | 1.32, 2.76 | 1.38 | 0.77, 2.48 | Two of four | 1.59 | 1.21, 2.09 | 1.22 | 0.89, 1.69 | One of four | 1.53 | 1.23, 1.89 | 1.19 | 0.93, 1.52 | HT-CD- MSDs-RD | 2.97 | 1.68, 5.25 | 2.86 | 1.18, 6.88 | Three of four | 2.16 | 1.50, 3.10 | 1.80 | 1.11, 2.91 | Two of four | 1.44 | 1.07, 1.92 | 1.50 | 1.08, 2.08 | One of four | 1.46 | 1.16, 1.82 | 1.22 | 0.97, 1.54 | HT-MSDs-DM-MD | 2.27 | 1.18, 4.38 | 2.62 | 1.85, 3.70 | Three of four | 1.43 | 1.01, 2.01 | 1.56 | 0.83, 2.95 | Two of four | 1.78 | 1.39, 2.29 | 1.34 | 0.96, 1.85 | One of four | 1.42 | 1.15, 1.75 | 1.20 | 0.95, 1.51 | HT-CD-DM-MD | 4.56 | 1.69, 12.29 | 1.84 | 0.44, 7.63 | Three of four | 2.14 | 1.51, 3.04 | 1.89 | 1.06, 3.40 | Two of four | 1.84 | 1.39, 2.44 | 1.29 | 0.95, 1.74 | One of four | 1.38 | 1.14, 1.67 | 1.24 | 0.97, 1.59 |
| Five diseasesa | | | | | HT-CD-MSDs-DM-MD | 6.15 | 2.32, 16.32 | 2.94 | 2.02, 4.29 | Four of five | 1.99 | 1.27, 3.12 | 3.63 | 0.94, 13.96 | Three of five | 2.36 | 1.66, 3.36 | 1.47 | 0.94, 2.32 | Two of five | 1.71 | 1.32, 2.21 | 1.35 | 0.99, 1.83 | One of five | 1.52 | 1.22, 1.91 | 1.28 | 0.99, 1.63 | HT-CD-MSDs-DM-RD | 3.65 | 0.91, 14.57 | † | | Four of five | 1.97 | 1.25, 3.10 | 4.60 | 2.62, 8.09 | Three of five | 2.57 | 1.76, 3.75 | 1.55 | 0.94, 2.53 | Two of five | 1.51 | 1.13, 2.00 | 1.61 | 1.17, 2.20 | One of five | 1.41 | 1.11, 1.79 | 1.27 | 0.97, 1.66 | HT-CD-MSDs-MD-RD | 4.14 | 1.24, 13.85 | † | | Four of five | 1.96 | 1.04, 3.69 | 3.11 | 1.73, 5.60 | Three of five | 2.03 | 1.38, 2.98 | 1.35 | 0.76, 2.40 | Two of five | 1.62 | 1.22, 2.14 | 1.33 | 0.96, 1.85 | One of five | 1.55 | 1.22, 1.96 | 1.22 | 0.95, 1.57 | HT-MSDs-DM-MD-RD | 2.77 | 0.54, 14.33 | † | | Four of five | 1.86 | 1.07, 3.23 | 1.27 | 0.28, 5.68 | Three of five | 1.68 | 1.22, 2.31 | 2.38 | 1.56, 3.65 | Two of five | 1.84 | 1.41, 2.40 | 1.40 | 1.01, 1.93 | One of five | 1.42 | 1.13, 1.79 | 1.30 | 1.00, 1.68 |
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