Serum Levels of Matrix Metalloproteinase-1 in Brazilian Patients with Benign Prostatic Hyperplasia or Prostate Cancer

Table 2

Correlation of levels and of genotypic groups for MMP-1 with clinical traits at admission.

	Age	BMI	HbA1c	TGL	TC
	(years)	(kg/m^2)	(%)	(mg/dL)	(mg/dL)
rs495366, GG vs AG vs AA	−0.03; 0.709	0.02; 0.813	−0.00; 0.945	−0.05; 0.474	0.00; 0.957
rs495366, GG vs A_	−0.01; 0.884	0.00; 0.960	−0.02; 0.768	−0.02; 0.745	0.02; 0.766
rs495366, G_ vs AA	−0.07; 0.332	0.06; 0.457	0.06; 0.436	−0.12; 0.094	0.06; 0.396
MMP-1, pg/mL	0.05; 0.511	0.05; 0.499	0.10; 0.181	0.05; 0.537	−0.03; 0.727
	Creatinin,	CRP,	TSH,	Total PSA,	MMP−1,
	mg/dL	mg/L	mU/L	ng/mL	ng/mL
rs495366, GG vs AG vs AA	−0.09; 0.237	−0.09; 0.249	0.03; 0.714	−0.06; 0.431	−0.14; 0.065
rs495366, GG vs A_	−0.06; 0.433	−0.06; 0.414	0.01; 0.935	−0.04; 0.605	−0.11; 0.134
rs495366, G_ vs AA	−0.14; 0.059	−0.13; 0.085	0.08; 0.252	−0.09; 0.208	−0.15; 0.045
MMP-1, ng/mL	0.11; 0.154	0.10; 0.168	0.01; 0.883	0.02; 0.753	−

Spearman’s correlation test was used. Data are expressed in correlation index and significance level (two digits represent r; three digits represent P). BMI: body mass index; HbA1c: glycated hemoglobin type-A1c; MMP-1: matrix metalloproteinase-1; TGL: triglycerides; TC: total cholesterol; TSH: thyroid stimulating hormone; PSA: prostate-specific antigen. Individuals with the GG, AG, and AA genotypes were, respectively, represented by 1, 2, and 3 in the analysis with all groups, whereas G homozygotes and carriers of the A-allele were represented by 1 and 2 in this order in the subsequent analysis. Significance threshold was set at .