Polymorphisms in HSD17B1: Early Onset and Increased Risk of Alzheimer’s Disease in Women with Down Syndrome

Table 3

Alzheimer's disease risk by HSD17B1 genotype in women with Down syndrome.

HSD17B1 genotype*	𝑁	AD	HR (95% CI)**
rs2830
CC	49	15 (30.6)	0.7 (0.3.5)
CT	101	31 (33.7)	0.9 (0.5–1.8)
TT	56	15 (26.8)	1.0 (reference)
rs2676530
AA	14	7 (50.0)	1.5 (0.7–3.3)
AG	75	17 (22.7)	0.7 (0.4–1.2)
GG	135	47 (34.8)	1.0 (reference)
rs676387
TT	22	9 (40.9)	2.7 (1.2–5.8)
GT	72	23 (31.9)	1.4 (0.8–2.4)
GG	129	40 (31.0)	1.0 (reference)
rs605059
CC	59	20 (33.9)	3.0 (1.4–6.8)
CT	107	34 (31.8)	2.0 (0.98–4.2)
TT	51	12 (23.5)	1.0 (reference)
rs598126
CC	58	15 (34.)	2.2 (1.1–4.4)
CT	119	37 (31.1)	1.4 (0.7–2.6)
TT	54	20 (27.8)	1.0 (reference)

**Hazard ratio for AD, adjusted for age, ethnicity, level of intellectual disability, BMI, and the presence of an APOE ε4 allele.
*Numbers vary because not all participants were genotyped for all SNPs.