Critical Care Research and Practice

Research Article

The Prognostic Value of Echocardiographic Wall Motion Score Index in ST-Segment Elevation Myocardial Infarction

Table 2

Univariable and multivariable associations with all-cause 30-day and 12-month mortality following acute ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous intervention (PCI) (N = 1181).


Variable	Univariable			value^e	Multivariable			value^e
Variable	OR (95% CI)	value	AUC (95% CI)	value^e	OR (95% CI)	value^e	AUC (95% CI)	value^e

30 Day mortality
WMSI^a	2.8 (2.1–3.9)	<0.001	0.85 (0.80–0.91)		2.4 (1.6–3.6)	<0.001	Model 1:
Age^b	2.6 (1.8–3.7)	<0.001			1.9 (1.2–3.1)	0.004	0.92 (0.87–0.97)
Anterior infarction	6.2 (2.3–16.5)	<0.001			3.6 (1.2–10.7)	0.021
eGFR^c	1.9 (1.6–2.4)	<0.001			1.5 (1.2–1.9)	0.001
Cardiogenic shock	18.5 (6.1–55.9)	<0.001			5.4 (1.1–26.7)	0.039

LVEF^d	3.0 (2.1–4.4)	<0.001	0.80 (0.71–0.87)	0.085	2.1 (1.3–3.2)	0.001	Model 2:	0.23
Age^b					1.8 (1.2–2.7)	0.007	0.93 (0.88–0.99)
Anterior infarction					3.9 (1.3–11.5)	0.013
eGFR^c					1.5 (1.2–2)	<0.001
Cardiogenic shock					5.5 (1.2–24.9)	0.027

GRACE risk score			0.63 (0.51–0.76)	0.001			0.63 (0.51–0.76)	<0.001
TIMI risk score			0.75 (0.65–0.85)	0.09			0.75 (0.65–0.85)	0.002

12-Month mortality
WMS^Ia	2.4 (1.9–3.1)	<0.001	0.77 (0.68–0.84)		2.3 (1.7–3.0)	<0.001	Model 3:
Age^a	2.4 (1.9–3.1)	<0.001			2.1 (1.5–3.0)	<0.001	0.89 (0.85–0.94)
FMCTB>120 mins	4.6 (2.5–8.3)	0.08			3.7 (1.9–7.3)	<0.001
eGFR^c	1.7 (1.5–1.9)	<0.001			1.3 (1.1–1.5)	0.004
Cardiogenic shock	12.0 (4.4–33.1)	<0.001			4.3 (1.2–15.6)	0.025
Current smoker	0.7 (0.3–1.2)	0.19			2.2 (1–5.1)	0.061

LVEF^d	2.4 (1.7–2.9)	<0.001	0.71^e (0.61–0.79)	0.034	1.8 (1.3–2.4)	<0.001	Model 4:	0.08
Age^a					2.0 (1.4–2.8)	<0.001	0.87 (0.83–0.92)
FMCTB>120 mins					3.3 (1.7–6.2)	<0.001
eGFR^c					1.3 (1.1–1.5)	0.001
Cardiogenic shock					5.0 (1.5–17.1)	0.01
Current smoker					2.1 (0.9–4.9)	0.07

GRACE risk score			0.63 (0.54–0.71)	0.007			0.63 (0.54–0.71)	<0.001
TIMI risk score			0.71 (0.62–0.79)	0.28			0.71 (0.62–0.79)	<0.001

Effects of continuous variables are reported as ^aper 0.4-unit increase; ^bper 10-year increase; ^cper 10 mL/min/1.73 m² unit decrease; ^dper 10% decrease. WMSI–Wall Motion Score Index; FMCTB–First Medical Contact to Balloon (minutes); eGFR–Estimated Glomerular Filtration Rate; ^e values for comparison of ROC areas for classifiers (LVEF, GRACE, TIMI) compared to WMSI (obtained from parametric ROC regression).