Research Article
Naloxegol to Prevent Constipation in ICU Adults Receiving Opioids: A Randomized Double-Blind Placebo-Controlled Pilot Trial
| Variable | Naloxegol, n = 6 | Placebo, n = 6 | value |
| Patients with ≥1 episode of diarrhea, N (%) | 4 (67) | 4 (67) | >0.99 | Time to first episode, hours, median (IQR) | 40 (19, 66) | 109 (48, 169) | 0.57 | Resolution of diarrhea within 24 hours after holding study drug and laxative protocol is stopped, N (%) | 2 (50) | 2 (50) | >0.99 | Persistence of diarrhea ≥48 hours after study drug is held and laxative protocol is stopped, N (%) | 2 (50) | 2 (50) | >0.99 | Use of a rectal tube, N (%) | 3 (75) | 1 (25) | 0.54 | Clinical opioid withdrawal scale | −0.1 ± 1.3 | +0.2 ± 1.3 | 0.31 | Difference in predose and postdose scores, mean ± SD |
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IQR: interquartile range; N: number; SD: standard deviation.
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