Baseline characteristics Statin user (n = 34,088) Nonstatin user (n = 94,073) Demographics Mean age (SD) 74.3 (11.4) 64.3 (19.0) <0.001 Sex, male 18,386 (53.9%) 44,476 (47.3%) <0.001 White 20,104 (59%) 45,278 (48.1%) <0.001 Black 3,394 (10%) 11,699 (12.4%) Hispanic 7,338 (21.5%) 28,359 (30.1%) Asian 2,914 (8.5%) 7,234 (7.7%) Others 338 (1%) 1,503 (1.6%) Comorbidity Liver disease 2,904 (8.5%) 10,472 (11.1%) <0.001 Chronic kidney disease 16,006 (47%) 24,040 (25.6%) <0.001 Heart failure 9,568 (28.1%) 14,531 (15.4%) <0.001 Chronic pulmonary disease 8,706 (25.5%) 19,219 (20.4%) <0.001 Ischemic heart disease 14,246 (41.8%) 19,622 (20.9%) <0.001 Rheumatological disease 867 (2.5%) 2,221 (2.4%) 0.06 Hypertension 31,236 (91.6%) 60,462 (64.3%) <0.001 Cerebrovascular disease 4,688 (13.8%) 8,523 (9.1%) <0.001 Diabetes mellitus 19,723 (57.9%) 33,074 (35.2%) <0.001 Dementia 4,597 (13.5%) 10,162 (10.8%) <0.001 Malnutrition 12,601 (37%) 31,745 (33.7%) <0.001 History of transplantation 987 (2.9%) 2,006 (2.1%) <0.001 History of GI bleed 5,452 (16%) 13,591 (14.4%) <0.001 Alcohol/drug use 3,101 (9.1%) 11,528 (12.3%) <0.001 AIDS/HIV 148 (0.4%) 573 (0.6%) 0.002 Hyperlipidemia 32,080 (94.1%) 50,931 (54.1%) <0.001 Charlson comorbidity index 0 2394 (7%) 25027 (26.6%) <0.001 1 3927 (11.5%) 14383 (15.3%) 2 5121 (15%) 13269 (14.1%) 3 4450 (13.1%) 9646 (10.3%) ≥4 18196 (53.4%) 31748 (33.7%) Medications Angiotensin receptor blockers 7,030 (20.6%) 9,177 (9.8%) <0.001 Beta-blockers 19,475 (57.1%) 28,383 (30.2%) <0.001 ACE inhibitors 17,256 (50.6%) 26,357 (28%) <0.001 Systemic corticosteroids 8612 (25.3%) 21360 (22.7%) <0.001 Disease modifying antirheumatic drugs 1,125 (3.3%) 3,101 (3.3%) 0.972
