Ketamine Boluses Are Associated with a Reduction in Intracranial Pressure and an Increase in Cerebral Perfusion Pressure: A Retrospective Observational Study of Patients with Severe Traumatic Brain Injury

Table 2

Variables independently associated with reduction in ICP and increase in CPP.

Variables	B value	95% CI	value
ICP
ICP prior to ketamine	−0.64	−0.77 to −0.51	<0.001
Days since admission	−1.23	−2.4 to −0.42	<0.003
Patient weight (kg)	0.08	0.01 to 0.17	0.04
Decompressive craniectomy	2.79	0.16 to 5.42	0.04
CPP
CPP prior to ketamine	−0.45	−0.55 to −0.34	<0.001
Paralytic infusion	8.71	3.58 to 13.84	0.001
Benzodiazepine bolus w/ketamine	6.99	0.27 to 13.71	0.04
Decompressive craniectomy	2.79	0.16 to 5.42	0.04