Beta-Blocker Therapy Preserves Normal Splenic T-Lymphocyte Numbers Reduced in Proportion to Sepsis Severity in a Sepsis Model

Figure 1

(a) Normal splenic T-lymphocyte numbers in sham operation mice (C) n = 5) and cecum ligation and puncture (CLP) mice at 3 different sites (CLP-D: cecal quarter site proximal to the ileocecal valve, CLP-M: midcecum, and CLP-P: cecal quarter site distal to the ileocecal valve; n = 5 per group). Normal T-lymphocyte numbers were decreased in proportion to CLP severity. (b) The percentage of T-lymphocyte apoptosis in 4 groups (C, CLP-D, CLP-M, and CLP-P). There were no significant differences in the percentage of apoptosis between the 4 groups. C: group C which received sham operation; CLP-D: group CLP-D which received CLP at the distal cecum; CLP-M: group CLP-M which received CLP at the midcecum; CLP-P: group CLP-P which received CLP at the proximal cecum.

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