Clinical Survey of Decreased Blood Flow Rate in Continuous Renal Replacement Therapy: A Retrospective Observational Study
Table 2
Comparison of clinical data between the two groups. Group 1: patients with a decreased blood flow rate during the therapeutic course of CRRT. Group 2: patients with a preserved blood flow rate.
Clinical characteristics
Group 1
Group 2
value
n = 52
n = 67
Age (years)
73
57–78
69
62–77
0.62
Male (n, %)
37
71.2
46
68.7
0.84
Height (cm)
164.4
158.0–170.5
160.5
152.8–168.8
0.10
Body weight (kg)
62.3
52.1–69.7
58
50.2–70.0
0.56
BMI (kg/m2)
22.4
19.6–26.2
23.2
20.6–25.8
0.76
Diabetes mellitus (n, %)
20
38.5
21
31.3
0.44
SBP (mmHg)
106
90–125
93
79–114
0.012
DBP (mmHg)
60
50–68
52
44–62
0.034
HR (/min)
102
85–120
91
69–106
0.016
Intubation (n, %)
17
32.7
25
37.3
0.70
SOFA score
12
10–15
12
10–15
0.82
Diagnosis at the time of starting CRRT
Sepsis or severe infectious diseases (n, %)
15
28.8
24
35.8
0.44
Heart failure (n, %)
14
26.9
20
29.9
0.84
After cardiovascular surgery (n, %)
15
28.8
10
14.9
0.07
Hepatic failure (n, %)
0
0
2
3.0
0.50
Mainly renal failure (n, %)
3
5.8
2
3.0
0.65
Tumor lysis syndrome (n, %)
0
0
0
0
0.50
Laboratory data
Alb (g/dL)
2.5
2.1–2.9
2.6
2.2–3.0
0.70
Hb (g/dL)
10.7
8.9–12.4
10.3
8.5–12.6
0.57
CRP (mg/dL)
11.8
5.7–19.1
8.0
3.6–17.6
0.38
Details of catheter
Triple lumen catheter (n, %)
41
78.8
46
68.7
0.30
Catheter position
Femoral vein (n, %)
44
84.6
51
76.1
0.36
Jugular vein (n, %)
8
15.4
16
23.9
0.36
Condition of CRRT
Mode of CRRT
CVVHDF (n, %)
44
84.6
56
83.6
1.00
CVVHD (n, %)
8
15.4
11
16.4
1.00
Type of hemofilter
PMMA (n, %)
20
38.5
31
46.3
0.46
CTA (n, %)
26
50.0
28
41.8
0.46
PS (n, %)
5
9.6
5
7.5
0.75
PES (n, %)
1
1.9
2
3.0
1.00
ACT (sec)
282
241–344
282
247–355
0.77
Clinical outcome
Catheter-related bloodstream infection (n, %)
13
25.0
7
10.4
0.048
All-cause death during CRRT (n, %)
22
42.3
33
49.3
0.47
All-cause death during hospitalization (n, %)
26
50.0
36
53.7
0.72
Physician who inserted hemodialysis catheter
Nephrologist (n, %)
30
57.7
36
53.7
0.71
Over 10 years of experience (n, %)
25
48.1
27
40.3
0.46
Continuous variables are presented as the median and interquartile range. Categorical variables are presented as number (n) and frequency (%). Continuous variables between two groups were compared using the Mann–Whitney U test, and categorical variables were compared using the Fisher exact probability test. ACT, activating coagulation time; Alb, albumin; BMI, body mass index; CRP, C-reactive protein; CRRT, continuous renal replacement therapy; CTA, cellulose triacetate; CVVHD, continuous venovenous hemodialysis; CVVHDF, continuous venovenous hemodiafiltration; DBP, diastolic blood pressure; Hb, hemoglobin; HR, heart rate; PES, polyethersulfone; PMMA, polymethylmethacrylate; PS, polysulfone; SBP, systolic blood pressure; SOFA score, sequential organ failure assessment score.
