High-Flow Nasal Interface Improves Oxygenation in Patients Undergoing Bronchoscopy
Table 1
Anthropometric, respiratory, and cardiovascular data under facial and different nasal interfaces.
Variables
V40
N40
N60
Baseline (, FiO2 = 0.21)
Gender (M/F)
9/6
8/7
7/8
Age (years)
68.0 (62.0–78.0)
70.0 (61.0–76.0)
64.0 (63.0–70.0)
BMI (kg/m2)
26.5 (22.5–29.1)
25.0 (21.4–28.0)
25.7 (21.2–28.9)
pH
7.45 (7.44–7.48)
7.47 (7.43–7.49)
7.46 (7.42–7.47)
PaCO2 (mmHg)
37.5 (35.0–42.1)
39.1 (37.3–41.5)
39.6 (33.4–42.5)
PaO2/FiO2
322.4 (295.6–374.3)
342.8 (295.7–371.9)
350.9 (304.3–363.8)
a/A PO2
0.674 (0.587–0.764)
0.723 (0.652–0.745)
0.718 (0.659–0.765)
PaO2 (mmHg)
67.7 (62.1–78.6)
72.0 (62.1–78.1)
73.7 (63.9–76.4)
SpO2 (%)
94 (93–96)
95 (91–96)
95 (93–97)
HR (bpm)
75.0 (62.0–97.0)
78.0 (72.0–85.0)
74.0 (68.0–84.0)
MAP (mmHg)
94.0 (90.0–107.0)
102.0 (92.0–112.0)
109.0 (100.0–117.0)
End of bronchoscopy (, FiO2 = 0.50)
pH
7.41 (7.38–7.44)*
7.41 (7.38–7.44)*
7.40 (7.36–7.40)*
PaCO2 (mmHg)
42.7 (41.0–44.4)*
43.2 (37.9–47.6)*
43.6 (42.4–48.0)*,+
PaO2/FiO2
165.0 (127.4 −199.2)*
140.6 (125.6–153.6)*
244.8 (181.6–366.8)+,++
a/A PO2
0.265 (0.207–0.326)*
0.224 (0.204 - 0.249)*
0.401 (0.295–0.604)*,+,++
PaO2 (mmHg)
82.5 (63.7–99.6)
70.3 (62.8–76.8)
122.4 (90.8–183.4)*,++
SpO2 (%)
94 (92–96)
92 (90–95)
98 (97–99)*,+,++
HR (bpm)
90 (76–110)*
84 (80–101)
84 (70–100)*
MAP (mmHg)
108.0 (92.0–126.0)
99.0 (94.0–105.0)
103.0 (93.0–117.0)
Duration (min)
14.0 (10.0–16.0)
15.0 (12.0–16.0)
15.0 (9.0–20.0)
10 minutes after bronchoscopy (, FiO2 = 0.35)
pH
7.42 (7.40–7.45)*
7.41 (7.39–7.44)*,**
7.40 (7.40–7.44)*,**
PaCO2 (mmHg)
42.2 (39.7–43.2)*
43.4 (41.0–45.7)*
40.7 (38.0–45.5)
PaO2/FiO2
248.6 (206.6–274.3)*,**
224.3 (206.6–249.1)*,**
278.8 (222.9–304.0)*
a/A PO2
0.441 (0.342–0.515)*,**
0.421 (0.352- 0.446)*,**
0.480 (0.389- 0.536)*
PaO2 (mmHg)
87.0 (72.3–101.8)
78.5 (72.3–87.2)
97.6 (78.0–106.4)*,**
SpO2 (%)
95 (92–98)
93 (91–95)
95 (95–98)**,+
HR (bpm)
82.0 (75.0–90.0)**
80.0 (79.0–91.0)*
76.0 (64.0–89.0)**
MAP (mmHg)
91.0 (83.0–103.0)
94.0 (85.0–98.0)**
96.0 (87.0–108.0)
Values are median (1st–3rd quartiles). V40, N40: patients that received oxygen (40 L/min, FiO2 = 0.5) through a Venturi mask and nasal prong; respectively, N60: patients that received oxygen (60 L/min, FiO2 = 0.5) through a nasal high-flow interface; baseline: FiO2 = 0.21; end of bronchoscopy: airflow according to V40, N40, and N60, FiO2 = 0.5; 10 min after bronchoscopy: 15 L/min, FiO2 = 0.35; PaCO2 and PaO2: arterial partial pressures of CO2 and O2; respectively, BMI: body mass index; PaO2/FiO2: ratio between PaO2 and inspiratory fraction of O2; a/A PO2: ratio between arterial and alveolar PO2; SpO2: peripheral oxygen saturation; HR: heart rate; MAP: mean arterial pressure, duration: length of bronchoscopy. *Significantly different from ; **significantly different from ; +significantly different from V40; ++significantly different from N40; significance level = 5%.
