Clinical Study
Epidemiology, Prognosis, and Evolution of Management of Septic Shock in a French Intensive Care Unit: A Five Years Survey
Table 1
Mortality risk factors in septic shock patients: monovariate analysis COPD: chronic obstructive pulmonary disease, SAPS: simplify acute physiology score, SOFA: sepsis-related organ failure assessment score, ICU: intensive care unit, RRT: renal replacement therapy, prothrombin ratio (PR).
| | Survivors 146 (45.6) | Deceased174 (54.4) | P |
| | Comorbidities (%) | | | | | Chronic cardiac failure | 21(14.4) | 36(21) | .1233 | | Diabete mellitus | 29(19.9) | 40(23.4) | .4479 | | COPD | 35(23.9) | 45(26.3) | .6321 | | Chronic liver failure | 11(7.5) | 24(14) | .0656 | | Chronic alcoolism | 28(19.1) | 57(33.3) | .0046 | | Chronic renal failure | 6(4.1) | 10(5.8) | .4810 | | Non hematologic malignancy | 16(10.9) | 20(11.6) | .8367 | | Hematologic malignancy | 16(10.9) | 16(9.3) | .6369 | | Immunosuppression | 25(17.1) | 24(14) | .4484 | | Clinical presentation | | | | | Male sex (%) | 92(63) | 111(63.8) | .8853 | | Age (years) (mean SD) | | | .0001 | | Lactate (meq/l) (mean SD) | | | .0001 | | Platelet count (1000/mm³) (mean SD) | | | .7813 | | Creatinine (mg/l) (mean SD) | | | .4825 | | Bilirubine (mg/l) (mean SD) | | | .0157 | | PR (%) (mean SD) | | | .0001 | | pH (mean SD) | | | .0007 | | PaO2/FiO2 (mean SD) | | | .0021 | | SAPS II (mean SD) | | | .0001 | | SOFA score (mean SD) | | | .0002 | | Respiratory failure (%) | 123(84.2) | 153(88.4) | .2746 | | Renal failure (%) | 30(20.5) | 53(31.1) | .0323 | | Coagulation failure (%) | 21(14.3) | 29(17.2) | .4869 | | Hepatic failure (%) | 1(0.7) | 10(6) | .0108 | | Neurologic failure (%) | 40(28.5) | 70(41.6) | .0169 | | Management | | | | | Time from shock to ICU admission (hours) (mean SD) | | | .6034 | | Adapted antibiotic therapy (%) (mean SD) | 138(97.8) | 154(96.8) | .7269 | | Time from sepsis to adapted antibiotic therapy (hours) (mean SD) | | | .1426 | | Adequate antibiotic therapy (%) | 89(92.7) | 76(83.5) | .0512 | | Time from sepsis to adequate antibiotic therapy (hours) (mean SD) | | | .1698 | | Mechanical ventilation (%) | 116(79.4) | 166(95.9) | .0001 | | Noninvasive ventilation (%) | 12(8.6) | 27(15.6) | .0614 | | Time from shock to intubation (hours) (mean SD) | | | .4050 | | RRT (%) | 41(28) | 57(33.1) | .3304 | | Time from shock to RRT (hours) (mean SD) | | | .9216 | | Cristalloid volume expansion at 6 hours of sepsis (mL) (mean SD) | | | .0135 | | Cristalloid volume expansion at 24 hours of sepsis (mL) (mean SD) | | | .0001 | | Hydrocortisone (%) | 123(84.2) | 147(84.4) | .9538 | | Time from shock to initiation of hydrocortisone (hours) (mean SD) | | | .5985 | | Activated proteine C (%) | 13(8.9) | 8(4.6) | .1246 | | Intensive insulin therapy (%) | 94(64.3) | 86(49.4) | .0072 | | Enteral nutrition (%) | 101(70.6) | 67(51.1) | .0009 | | Parenteral nutrition (%) | 39(27.2) | 29(22.1) | .3256 | | Time from shock to initiation of nutrition (days) (mean SD) | | | .7918 |
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