Translationally Controlled Tumor-Associated Protein
1Department of Surgery, The Methodist Hospital Research Institute, The Methodist Hospital System, Houston, TX, USA
2Cell Cycle Group, Institute of Genetics and Development of Rennes, Faculty of Medicine, University of Rennes 1, CNRS UMR 6061, Rennes, France
Translationally Controlled Tumor-Associated Protein
Description
Translationally Controlled Tumor-Associated Protein (TCTP) has been discovered in 1983 in mouse erythroleukemia cells. Over the years, it became evident that TCTP is an important player in a number of basic cell physiology events in cancer, embryo development, cell cycle, apoptosis, proliferation, growth, stress response, allergy, gene regulation, and heat-shock response. However, despite the nearly three decades of research, we only start to understand the role of TCTP in animal and plant embryo development through its participation in cell cycle, proliferation, and growth regulation, and the exact role(s) of TCTP in many complex cellular processes still remain(s) a mystery. One of the key questions in cancer research is the role of TCTP in tumor reversion, the rare event leading to tumor regression, and a “miraculous” cure; is TCTP involved in gene regulation or rather modification of the cytoskeleton of cancer cells during this process? We invite authors to submit original research and review papers that seek to understand the role of TCTP in cell physiology and pathology. We are interested in articles that explore various aspects of molecular, structural, and physiological role of TCTP in different cellular systems. Potential TCTP topics include, but are not limited to:
- Structure and interaction with other proteins
- Role in gene regulation
- Involvement in cytoskeleton regulation
- Function in cancer
- Role in apoptosis
- Role in cell growth, proliferation, and cell cycle
- Translational and posttranslational regulation
Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/bcri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: