Antiatherosclerotic and Cardioprotective Potential of Acacia senegal Seeds in Diet-Induced Atherosclerosis in Rabbits

Table 3

Effects of Acacia senegal seed extract (AS, 500 mg/kg/day, p.o.) or statin (0.25 mg/kg/day, p.o.) treatment for 45 days on the alteration in liver, heart, kidney, and aorta weight, all in gm/Kg body weight in hypercholesterolemic (Chol) diet fed atherosclerotic male rabbits.

Groups	Liver	Heart	Kidney	Aorta
Control	26.34 ± 1.35	2.12 ± 0.18	6.74 ± 0.41	0.16 ± 0.05
Chol	40.01 ± 1.35^c	2.85 ± 0.12^d	7.23 ± 0.48^d	0.41 ± 0.17^c
Chol + AS	24.65 ± 1.51^d,g	2.12 ± 0.17^d,h	6.29 ± 0.43^d,h	0.25 ± 0.13^c,g
Chol + statin	25.76 ± 1.32^d,g	2.57 ± 0.14^d,h	6.67 ± 0.32^d,h	0.27 ± 0.12^c,g

Data are means ± S.E.M. ( = 8); ≤ 0.001; nonsignificant as compared to the respective control values; ≤ 0.001; and nonsignificant as compared to the respective values of the Chol diet fed group.