Antiatherosclerotic and Cardioprotective Potential of Acacia senegal Seeds in Diet-Induced Atherosclerosis in Rabbits

Table 1

Effects of Acacia senegal seed extract (AS, 500 mg/kg/day, p.o.) or statin (0.25 mg/kg/day, p.o.) treatment for 45 days on the alteration in plasma concentration of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol (VLDL-C), all in mg/dL and on TC/HDL-C ratio and on atherogenic index in hypercholesterolemic (Chol) diet fed atherosclerotic male rabbits.

Groups	TC	TG	HDL-C	LDL-C	VLDL	CHO/HDL
Control	89.48 ± 6.25	101.40 ± 8.23	32.31 ± 1.3	37.60 ± 5.1	20.40 ± 1.2	2.98 ± 0.02
Chol	523.59 ± 33.66^c	366.72 ± 15.23^c	32.31 ± 1.2^d	419.41 ± 6.50^c	73.37 ± 2.38^c	17.47 ± 0.69^c
Chol + AS	92.50 ± 6.43^d,g	148 ± 12.80^a,g	29.50 ± 2.11^d,h	35.05 ± 1.39^d,g	28.50 ± 2.36^b,g	3.12 ± 0.22^a,g
Chol + statin	84.49 ± 4.79^d,g	95.86 ± 07.72^d,g	29.79 ± 1.58^d,h	35.67 ± 4.43^d,g	20.85 ± 2.33^d,g	2.81 ± 0.14^a,g

Data are means ± S.E.M. ( = 8); ≤ 0.05; ≤ 0.01; ≤ 0.001; and nonsignificant as compared to the respective control values. ≤ 0.001 and nonsignificant as compared to the respective values of the Chol diet fed group.