Collagen Content in Skin and Internal Organs of the Tight Skin Mouse: An Animal Model of Scleroderma

Table 3

Summary of published data showing skin thickness and hydroxyproline content in Tsk/+ and control mice.

Strain background	Genotype	No. of mice studied	Age	Gender	Dermal thickness (mm)	Fold change in dermal thickness^b	Fold change in collagen or hydroxyproline content^b	Reference
B10.D2(58N)/Sn	Normal	5	6 months	NG^a	1.1±0.1			Jimenez et al., 1984 [6]
B10.D2(58N)/Sn	Tsk	5	6 months	NG	2.2±0.1	2.0	2.5
NZB	pa/+	2	NG	NG				Bocchieri et al., 1993 [19]
NZB	Tsk/+	2	NG	NG			2.3
C57BL/6	pa/pa	5	2-3 months	NG	~0.180			Ong et al., 1999 [15]
BALB/c, C57BL/6	Tsk/+ IL4+/+, STAT6+/+	5	2-3 months	NG	~0.380	2.1
BALB/c, C57BL/6	Tsk/+ IL4−/−, STAT6+/+	5	2-3 months	NG	~0.190	1.0
BALB/c, C57BL/6	Tsk/+ IL4+/−, STAT6+/+	5	2-3 months	NG	~0.290	1.6
BALB/c, C57BL/6	Tsk/+ IL4+/+, STAT6+/−	5	2-3 months	NG	~0.160	0.8
BALB/c, C57BL/6	Tsk/+ IL4+/+, STAT6−/−	5	2-3 months	NG	~0.170	0.9
C57BL/6	pa/pa	6	NG	NG	0.132±0.042			McGaha et al., 2001 [20]
C57BL/6	Tsk/+ pa/+	13	NG	NG	0.228±0.072	1.7	2.0
BALB/c, C57BL/6	Tsk/+, Il4Rα+/−	9	NG	NG	0.243±0.088	1.8	1.5
BALB/c, C57BL/6	Tsk/+, Il4Rα−/−	9	NG	NG	0.135±0.031	1.0	0.9
C57BL/6	Tsk/+, Tgfb+/−	16	NG	NG	0.164±0.078	1.2	0.8
C57BL/6	+/+, Tgfb+/−	3	NG	NG	0.120±0.018	0.9	0.8
C57BL/6	pa/pa	6	3 months	NG	0.118±0.021			Kodera et al., 2002 [16]
C57BL/6	Tsk/+ pa/+	13	3 months	NG	0.232±0.089	1.9
BALB/c, C57BL/6	Tsk/+, Il4+/+	6	3 months	NG	0.327±0.081	2.7
BALB/c, C57BL/6	Tsk/+, Il4+/−	12	3 months	NG	0.205±0.091	1.7
BALB/c, C57BL/6	Tsk/+, Il4−/−	27	3 months	NG	0.143±0.042	1.2
BALB/c, C57BL/6	Tsk/Tsk, Il4+/−	5	3 months	NG	0.162±0.023	1.4
BALB/c, C57BL/6	Tsk/Tsk, Il4−/−	5	3 months	NG	0.139±0.019	1.2
C57BL/6	+/+	NG	3 months	Female	~0.160			Saito et al., 2002 [21]
C57BL/6	Tsk/+	NG	3 months	Female	~0.390	1.1	1.25
C57BL/6, 129	CD19 −/−	NG	3 months	Female	~0.160	1.0	1.0
C57BL/6, 129	Tsk/+, CD19 −/−	NG	3 months	Female	~0.320	1.0	1.1
C57BL/6	+/+	11	NG		0.206±0.021			Del Prete et al., 2004 [22]
C57BL/6	Tsk/+	8	NG		0.182±0.089
C57BL/6	+/+	23	6 weeks	Male	~0.8			Baxter et al., 2005 [23]
C57BL/6	Tsk/+ pa/+	34	6 weeks	Male	~1.5	2.0

aNG: not given. ^bFold change is shown compared to control.