Strategies to Identify Recognition Signals and Targets of SUMOylation
Figure 7
Molecular functions and canonical pathways regulated by SUMOylation. Ingenuity (IPA) analysis of proteins reported to be SUMO-modified in the PhosphoSitePlus (http://www.phosphosite.org/) and 3 recent MS studies [39, 75, 76]. (a) The top molecular functions are indicated. A dominant link to gene expression has been found. All functions are superior to the threshold (yellow line). (b) The top canonical pathways are indicated. All shown pathways are superior to the threshold. The Canonical Pathways that are involved in this analysis are displayed along the x-axis. The right y-axis displays the ratio up to 0.6. The ratio is calculated as follows: number of genes in a given pathway that meet cut-off criteria, divided by total number of genes that make up that pathway. Therefore y-axis displays the results importance. For the ratio, taller bars have more genes associated with the Canonical Pathway than shorter bars. The graph displaying the various pathways is presented from largest ratio to smallest ratio.
