The Ubiquitin-Proteasome System in Huntington’s Disease: Are Proteasomes Impaired, Initiators of Disease, or Coming to the Rescue?

Figure 2

Localization of proteasomes in polyQ aggregates. Upon expression of red-labeled polyQ peptides in Hela cells, initially small aggregates appear (upper panel) which also recruit green-labeled proteasomes. However, in larger polyQ peptide containing aggregates the proteasome is only present in the outer layers, suggesting that proteasomes are not irreversibly trapped in aggregates.