Review Article
Ubiquitin C-Terminal Hydrolase L1 in Tumorigenesis
Table 1
Aberrant expression of UCH-L1 in tumor tissues and cancer cells.
| Elevated UCH-L1 | Down-Regulated UCH-L1 |
| Malignant Tumors |
| Squamous cell carcinoma [31] | Prostate tumors [46] | Medullary thyroid carcinoma tumors [38] | Primary breast cancer tumors [16] | Osteosarcoma [45] | Primary nasopharyngeal carcinoma [10] | Adenocarcinoma [35] | Colorectal carcinoma [47] | Metastatic colorectal cancer tumors [9] | Melanoma [48] | Breast cancer tumors [37] | Diffuse-type gastric cancer [34] | Pancreatic ductal carcinoma tumors [36] | | Parathyroid carcinoma [49] | |
| Transformed Cells |
| SaOS-2 osteosarcoma cells [45] | LNCaP prostate cancer cells [50] | BLZ-211 and BLS-211 bladder cancer cells [43] | | BL30, X-50/7, KR4, Raji, KR4 B-cell lymphoma cells [44] | | HCT8 colorectal cancer cells [9] | | DU154 prostate cancer cells [41, 42] | | H157, W138, H358 lung carcinoma cells [8] | |
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