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Study | Study design | Study population | Main findings |
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Chen et al. 2017 [18] | Case-control, years | adults (mean age: 41 years) with epilepsy on ≥1 AED, of which TPM: 639 | PBAR in 17.2%, leading to dose reduction or discontinuation in 13.8% (all patients) and 6.3% (TPM users). |
Chung et al. 2007 [50] | Case-control, years | adults (mean age 38.5 years) on different AEDs (LEV: 196, LTG: 251, OXC: 97, TPM: 156, ZNS: 128) | TPM with the highest rate of discontinuation (55.8%), but only few due to PBAR (5 of 156 patients). |
Endoh et al. 2012 [54] | Case-control, months | children with epileptic spasms, of which 33 used TPM | 5 of 33 patients (15.2%) developed irritability. |
Grosso et al. 2005 [81] | Cohort study, months | children < 2 years (mean age: 13 months) on TPM | Irritability is one of the most common adverse reactions. |
Kanner et al. 2003 [82] | Cohort study, months | patients (mean age: 36.1 years) with epilepsy using TPM as monotherapy or add-on | PBAR in 12.6%, incl. aggression (10.7%), irritability (5.7%), and depression (5%). TPM discontinued in 27% with these adverse reactions. |
Lee et al. 2011 [55] | Cohort study, weeks | children (2-18 months) with infantile spasms using TPM | Irritability in 4 patients (14.3%; most common adverse reaction). |
Mula et al. 2003 [38] | Cohort study, months | patients (mean age 35.8 years) with epilepsy using TPM | PBAR in 24% (aggression: 5.6%). |
Mula and Trimble 2003 [56] | Cohort study, months | patients on TPM | Mood symptoms in almost half of patients. Aggression is the second most common (23%), resolved after dose reduction or discontinuation of TPM. |
Mula et al. 2007 [67] | Case-control, years | patients with epilepsy, treated with LEV and TPM (consecutively) | PBAR in 30% |
Reith et al. 2003 [83] | Case-control, days | < 18 years (mean age: 8.1 years) with epilepsy using TPM; follow-up of of these | Aggression or psychosis treatment-limiting in 10 of 127 patients (7.9%). |
Weintraub et al. 2007 [27] | Case-control, months | of which 112 patients (mean age: 41 years) used TPM | PBAR in 6.3% on TPM, which was lower than the mean frequency of all AEDs (8.4%) |
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