With the rapid increase of protein sequences in the postgenomic era, it is desired to develop the computational approaches that can derive and analyze useful information from them to promote the development of biomedicine and drug design. Meanwhile, in order to understand the protein-protein interactions and other complex interactions in a living system, a new discipline, called “Systems Biology”, is created.

This special issue focuses on recent research progress on the computational methods of systems biology in molecular biology, chemistry biology, molecular biomedicine, and biopharmacy. We invite authors to contribute review and research papers addressing the open biology and biomedicine problems with the computational and mathematical approaches. Potential topics include, but are not limited to:

• Substrate-enzyme-product interaction
• Systems biology approaches for personalized medicine
• Disease biomarker discovery by computer
• Multiscale and multilevel modeling in biomedicine
• Protein subcellular location and function classification based on the network
• The dynamics of the bimolecular networks and their biological functions
• Construction and analysis of SNP networks
• Developing and analyzing the protein modification network

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/bioinformatics/csb/ according to the following timetable: