BioMed Research International

Immunopathology of Parasitic Infections and Therapeutic Approaches in Humans and Animals

Publishing date
27 May 2016
Submission deadline
08 Jan 2016

1University of Naples Federico II, Naples, Italy

2University of Queensland, Gatton, Australia

3Warmia and Mazury University in Olsztyn, Olsztyn, Poland

4Universidad Nacional Autonoma de Mexico, Mexico City, Mexico

5Ghent University, Merelbeke, Belgium

Immunopathology of Parasitic Infections and Therapeutic Approaches in Humans and Animals


Immune mechanisms are involved in the pathology of many parasitic infections. The main factors responsible for tissue injury during parasitic infections are chronicity of the infections, release of parasitic or host cells in tissues and blood, alteration and destruction of host tissue, presence of antigenic components shared by the host and the parasite, and relative inefficiency of the host in eliminating the antigens or cross-reacting antibodies. Parasitic infections are commonly asymptomatic. Pathology often occurs in individuals having reduced immunity and being therefore highly susceptible to the infection with high parasitic burdens. Pathology can also occur in individuals that are highly immunologically reactive, despite having low parasitic burdens. In this case, a breakdown of the immune-regulatory environment established by the host and the parasite may have occurred. Much attention has to be focused on the immune system that could be considered a therapeutic target for a new approach against parasitic infections.

We invite investigators to submit original research articles and reviews that will contribute to the general knowledge of immunity during parasitic infections, with particular emphasis on emerging and reemerging parasitic diseases, mainly including the following:

  • Vector-borne parasitic diseases (e.g., caused by Leishmania, Babesia, and Dirofilaria)
  • Foodborne and waterborne parasitic diseases (e.g., caused by Cryptosporidium, Giardia, Blastocystis, Toxoplasma, Sarcocystis, Echinococcus, and Trichinella)
  • Ectoparasitic diseases (e.g. pediculosis, myiasis, tungiasis, scabies, and arthropod infestations)

We are particularly interested in articles investigating any aspect of the immune modulation to the aforementioned parasitic diseases, such as

Potential topics include, but are not limited to:

  • Characterization of the cell phenotype during parasitic diseases
  • Cell-cell interactions and molecular mechanisms regulating the immune response to parasites
  • Mechanisms of immune-evasion implemented by parasites
  • Evidences of autoimmune diseases and immune-driven pathology associated with parasitic diseases
  • Suppression of autoimmunity by parasitic diseases
  • Immunological impact of parasite coinfections
  • New advances in the field of parasite-induced carcinogenesis
  • New approaches and techniques for investigating immune response in parasitic diseases (e.g., in vivo techniques)
  • Advances in diagnostic techniques for parasite characterization
  • Coinfections (e.g., HIV/TB/malaria and neglected parasitic/nonparasitic diseases)
  • New advances in therapy of parasitic diseases


  • Special Issue
  • - Volume 2016
  • - Article ID 8213532
  • - Editorial

Immunopathology of Parasitic Infections and Therapeutic Approaches in Humans and Animals

Orlando Paciello | Chiara Palmieri | ... | Peter Geldhof
  • Special Issue
  • - Volume 2016
  • - Article ID 8634603
  • - Review Article

Role of Macrophages in the Repair Process during the Tissue Migrating and Resident Helminth Infections

Berenice Faz-López | Jorge Morales-Montor | Luis I. Terrazas
  • Special Issue
  • - Volume 2016
  • - Article ID 8016186
  • - Research Article

Immunopathological Features of Canine Myocarditis Associated with Leishmania infantum Infection

Alessandro Costagliola | Giuseppe Piegari | ... | Orlando Paciello
  • Special Issue
  • - Volume 2016
  • - Article ID 3575468
  • - Research Article

Histological Lesions and Cellular Response in the Skin of Alpine Chamois (Rupicapra r. rupicapra) Spontaneously Affected by Sarcoptic Mange

Claudia Salvadori | Guido Rocchigiani | ... | Alessandro Poli
  • Special Issue
  • - Volume 2016
  • - Article ID 1567254
  • - Research Article

Biosensor for Hepatocellular Injury Corresponds to Experimental Scoring of Hepatosplenic Schistosomiasis in Mice

Martina Sombetzki | Nicole Koslowski | ... | Martin Sauer
  • Special Issue
  • - Volume 2016
  • - Article ID 7985104
  • - Research Article

Development of a Murine Infection Model with Leishmania killicki, Responsible for Cutaneous Leishmaniosis in Algeria: Application in Pharmacology

Naouel Eddaikra | Ihcene Kherachi Djenad | ... | Zoubir Harrat
BioMed Research International
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Acceptance rate31%
Submission to final decision76 days
Acceptance to publication53 days
Impact Factor2.197

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