Ectonucleotidases in Cancer and Inflammation
1University of Montreal, Faculty of Pharmacy, Notre-Dame Hospital, 1560 Sherbrooke Street, Montreal, Quebec, Canada H2L 4M1
2Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, OK 73104-5097, USA
3Immunology Research Centre, St. Vincent's Hospital Melbourne, Fitzroy, VIC 3065, Australia
Ectonucleotidases in Cancer and Inflammation
Description
Ectonucleotidases and activation of purinergic receptors are now well recognized as a ubiquitous means of intercellular communication, regulating key physiological functions. Recent studies suggest that ectonucleotidases are involved in the pathophysiology of inflammatory diseases and cancer. Recent advances in biology have introduced new technologies to study the role of ectonucleotidases.
We invite investigators to contribute original research articles as well as review articles on the molecular and cellular pathways underlying the interactions between ectonucleotidases, cancer, and inflammation. We are particularly interested in articles describing potential therapeutic interventions aimed at modulating ectonucleotidases activity, advances in purinergic receptor signaling, new insights into the role of extracellular adenosine in cancer, and current concepts in purinergic receptor-mediated immune modulation. Potential topics include, but are not limited to:
- Ectonucleotidases in inflammatory diseases
- Ectonucleotidases in tumor immune escape
- Ectonucleotidases in cancer metastasis
- Adenosine receptor signaling and inflammation
- Ectonucleotidases in solid cancer
- Ectonucleotidases in leukemia/lymphomas
- Ectonucleotidases in transplantation
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