BioMed Research International

Inverting T-Cell Exhaustion in Hematological Malignancies


Publishing date
01 Apr 2021
Status
Closed
Submission deadline
27 Nov 2020

Lead Editor

1Jinan University, Guangzhou, China

2Polish Academy of Sciences, Poznan, Poland

3Chinese Academy of Sciences, Guangzhou, China

4University of Macau, Macau, China

This issue is now closed for submissions.

Inverting T-Cell Exhaustion in Hematological Malignancies

This issue is now closed for submissions.

Description

T-cell immunotherapies, such as CAR-T and TCR-T-cell therapies, play an important role in treating hematological malignancies (HM), including leukemia, lymphoma, and multiple myeloma. However, T-cell senescence and exhaustion, which may be induced by tumor microenvironment or leukemia cells, limit the clinical effects of T-cell therapy.

One of the major reasons is the upregulation of T-cell inhibitory receptors (immune checkpoints), such as programmed cell death receptor-1 (PD-1), cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), T-cell immunoglobulin mucin-domain-containing-3 (Tim-3) and T-cell lymphocyte activation gene-3 (LAG-3, and similar. Significantly, immune checkpoint inhibitors can restore the anti-tumor effects of T-cells in cancer patients, however these immunotherapy effects can be inconsistent. This could be due to the heterogeneity of the immune system, but this link remains unclear.

This Special Issue aims to collect original research articles which focus on revealing the characteristics and mechanisms of T-cell senescence and exhaustion in HM, and further exploring approaches to inverse T-cell senescence and exhaustion for T-cell immunotherapy. Review articles which summarize the current advances of T-cell immunotherapy based on inversion of T-cell senescence and exhaustion of HM are also welcomed.

Potential topics include but are not limited to the following:

  • Characteristics of T-cell senescence and exhaustion in patients with HM
  • Influence factors of T-cell senescence in HM
  • Molecular mechanism of T-cell exhaustion in HM
  • Heterogeneity of immunotherapy effects based on immune checkpoint inhibitors
  • T cell exhaustion inversion combining CAR-T-cell therapy
  • Antibody-based therapy in HM
  • Novel potential biomarkers for T-cell immunotherapy

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 6616391
  • - Review Article

T Cell Exhaustion and CAR-T Immunotherapy in Hematological Malignancies

Lu Tang | Yinqiang Zhang | ... | Heng Mei
  • Special Issue
  • - Volume 2020
  • - Article ID 8765028
  • - Review Article

Chimeric Antigen Receptor T Cell Exhaustion during Treatment for Hematological Malignancies

Chunyi Shen | Zhen Zhang | Yi Zhang
  • Special Issue
  • - Volume 2020
  • - Article ID 9531549
  • - Research Article

Increased Expression of TIGIT/CD57 in Peripheral Blood/Bone Marrow NK Cells in Patients with Chronic Myeloid Leukemia

Danlin Yao | Ling Xu | ... | Yuhong Lu
  • Special Issue
  • - Volume 2020
  • - Article ID 4241864
  • - Review Article

Application of Chimeric Antigen Receptor T Cells in the Treatment of Hematological Malignancies

Weiqi Yan | Zhuojun Liu | ... | Jian Yu
  • Special Issue
  • - Volume 2020
  • - Article ID 4956946
  • - Review Article

Antibody-Based Immunotherapeutic Strategies for the Treatment of Hematological Malignancies

Yizhao Han | Zhuojun Liu | ... | Jian Yu
  • Special Issue
  • - Volume 2020
  • - Article ID 4612952
  • - Research Article

Characteristic of TIGIT and DNAM-1 Expression on Foxp3+ γδ T Cells in AML Patients

Zhenyi Jin | Wanyi Ye | ... | Xiuli Wu
  • Special Issue
  • - Volume 2020
  • - Article ID 6215435
  • - Research Article

KIR3DL1 and HLA-Bw4 Interaction Showed a Favorable Role in Patients with Myelodysplastic Syndromes in Chinese Southern Han

Jian Xin Zhen | Si Qi Cai | ... | Zhi Hui Deng
BioMed Research International
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