BioMed Research International

ω-3 PUFAs in the Prevention and Cure of Inflammatory, Degenerative, and Neoplastic Diseases 2014


Status
Published

1Catholic University, Rome, Italy

2National Taiwan University, Taipei, Taiwan

3Charité University Medicine Berlin, Berlin, Germany

4Wake Forest School of Medicine, Winston-Salem, USA

5Chungnam National University, Daejeon, Republic of Korea


ω-3 PUFAs in the Prevention and Cure of Inflammatory, Degenerative, and Neoplastic Diseases 2014

Description

Omega-3 polyunsaturated fatty acids ( ω-3 PUFA) are dietary components that have attracted considerable interest for their potential role in the prevention and cure of different chronic diseases. It is believed that their increased intake may overcome the imbalance between the lack of ω-3 PUFA consumption and the excess of ω-6 PUFA existing in most diets. A number of molecular mechanisms have been proposed to explain their effects: (1) incorporation into cell membranes phospholipids, where they may substitute the ω-6 PUFA arachidonic acid (AA) and prevent the formation of AA-derived bioactive compounds with proinflammatory and procarcinogen potential; moreover, they may alter the physical-chemical properties of lipid membrane microdomains in the cells, and modulate the activities of receptors, enzymes, and carriers located there; (2) metabolic conversion into highly potent bioactive lipids mediators with proresolving and protective action towards inflammation and cell degeneration; (3) modulation of cell redox status.

However, also due to recent clinical data, many doubts still exist regarding the magnitude of these effects in the clinic, as well as regarding optimal and safe dietary doses of ω-PUFA, and concerning the safety and bioavailability of their sources.

We invite investigators to contribute original research and review articles that could help in broadening the current knowledge on the role of ω-3 PUFA in human health and the molecular mechanisms underlying their effects.

Potential topics include, but are not limited to:

  • ω-3 PUFA and inflammation
  • ω-3 PUFA and immune function
  • ω-3 PUFA and cardiovascular diseases
  • ω-3 PUFA and the metabolic syndrome
  • ω-3 PUFA in brain development and diseases
  • ω-3 PUFA and learning memory
  • ω-3 PUFA and Alzheimer’s disease
  • ω-3 PUFA and aging
  • ω-3 PUFA and cancer
  • ω-3 PUFA and membrane microdomains
  • ω-3 PUFA-derived bioactive lipid mediator
  • ω-3 PUFA receptors and sensors
  • ω-3 PUFA and the regulation of gene expression
  • ω-3 PUFA dietary recommendations
  • Novel sources of ω-3 PUFA
  • Safety and biodistribution of ω -3 PUFA

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 695875
  • - Editorial

ω-3 PUFAs in the Prevention and Cure of Inflammatory, Degenerative, and Neoplastic Diseases 2014

Karsten H. Weylandt | Yong Q. Chen | ... | Gabriella Calviello
  • Special Issue
  • - Volume 2015
  • - Article ID 712363
  • - Review Article

Omega-3 Polyunsaturated Fatty Acids Intake to Regulate Helicobacter pylori-Associated Gastric Diseases as Nonantimicrobial Dietary Approach

Jong-Min Park | Migyeong Jeong | ... | Ki-Baik Hahm
  • Special Issue
  • - Volume 2015
  • - Article ID 501792
  • - Review Article

Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives

Chiara Cipollina
  • Special Issue
  • - Volume 2015
  • - Article ID 768478
  • - Research Article

Heterologous Reconstitution of Omega-3 Polyunsaturated Fatty Acids in Arabidopsis

Sun Hee Kim | Kyung Hee Roh | ... | Jong-Bum Kim
  • Special Issue
  • - Volume 2015
  • - Article ID 239764
  • - Research Article

Docosahexaenoic Acid Induces Cell Death in Human Non-Small Cell Lung Cancer Cells by Repressing mTOR via AMPK Activation and PI3K/Akt Inhibition

Nayeong Kim | Soyeon Jeong | ... | Kyu Lim
  • Special Issue
  • - Volume 2015
  • - Article ID 137097
  • - Review Article

Effect of Dietary ω-3 Polyunsaturated Fatty Acid DHA on Glycolytic Enzymes and Warburg Phenotypes in Cancer

Laura Manzi | Lara Costantini | ... | Nicolò Merendino
  • Special Issue
  • - Volume 2015
  • - Article ID 830930
  • - Review Article

Biological Roles of Resolvins and Related Substances in the Resolution of Pain

Ji Yeon Lim | Chul-Kyu Park | Sun Wook Hwang
  • Special Issue
  • - Volume 2015
  • - Article ID 360825
  • - Research Article

The Pharmacokinetic Profile of a New Gastroresistant Capsule Preparation of Eicosapentaenoic Acid as the Free Fatty Acid

Eleonora Scaioli | Carla Cardamone | ... | Andrea Belluzzi
  • Special Issue
  • - Volume 2015
  • - Article ID 581469
  • - Review Article

N-3 Polyunsaturated Fatty Acids and Inflammation in Obesity: Local Effect and Systemic Benefit

Yue Wang | Feiruo Huang
  • Special Issue
  • - Volume 2015
  • - Article ID 653750
  • - Review Article

The Role of Omega-3 Polyunsaturated Fatty Acids in the Treatment of Patients with Acute Respiratory Distress Syndrome: A Clinical Review

M. García de Acilu | S. Leal | ... | J. R. Masclans
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision76 days
Acceptance to publication53 days
CiteScore2.410
Impact Factor2.197
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