Some genotoxic conditions can produce a wide variety of effects on human health. Some of these effects appear immediately, whereas others do not become evident until much later. Several chronic diseases have been studied for its mechanism of perpetuation of clinical complications and the development of secondary diseases such as cancer. Oxidative stress and, therefore, genomic instability have gained growing attention in understanding this process.

Genetic instability due to increased DNA damage has an important impact on the pathogenesis of chronic disease. Common effects of DNA damage are interference with fundamental cell features such as cell differentiation, DNA repair, epigenetic marking, cell cycle regulation, and apoptosis. Potential topics include, but are not limited to:

• Oxidative stress markers
• DNA damage detection techniques
• Free radicals in human disease
• DNA damage in human disease
• Inflammation and oxidative stress
• Chromosome instability syndromes
• Epigenetic modifications and human disease
• Antioxidants and DNA protectors

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