Research Article

Vitamin E Loaded Naringenin Nanoemulsion via Intranasal Delivery for the Management of Oxidative Stress in a 6-OHDA Parkinson’s Disease Model

Table 2

NE formulation composition and physical screening studies.

Formulation codeSurfactant  :  co-surfactant ratio Oil %
%Water %
Physical Stability testInference
SurfactantCo-surfactant HeatingFreeze thaw cycle Centrifugation

F14:11032850Passed
F22025550---Failed
F318.1821.825.4554.55---Failed
F414.0416.844.2164.91---Failed
F511.9414.333.5870.15Passed
F614.8123.715.9255.56--Failed
F711.6318.614.6565.12Passed
F811.1119.44519.44550Passed
F91017.517.555--Failed
F108.8915.5515.5560--Failed
F117.7513.5613.5665.12--Failed
F126.6711.66511.66570Passed
F137.4918.72518.72555--Failed
F146.6716.66516.66560Passed
F155.814.49514.49565.22Passed
F16512.512.570--Failed

NE formulation composition and physical screening studies, results of which demonstrated that the formulations prepared from the ratio of 4:1 passed the physical stability test.