Vitamin E Loaded Naringenin Nanoemulsion via Intranasal Delivery for the Management of Oxidative Stress in a 6-OHDA Parkinson’s Disease Model
Table 2
NE formulation composition and physical screening studies.
Formulation code
Surfactant : co-surfactant ratio
Oil %
%
Water %
Physical Stability test
Inference
Surfactant
Co-surfactant
Heating
Freeze thaw cycle
Centrifugation
F1
4:1
10
32
8
50
✓
✓
✓
Passed
F2
20
25
5
50
-
-
-
Failed
F3
18.18
21.82
5.45
54.55
-
-
-
Failed
F4
14.04
16.84
4.21
64.91
-
-
-
Failed
F5
11.94
14.33
3.58
70.15
✓
✓
✓
Passed
F6
14.81
23.71
5.92
55.56
✓
-
-
Failed
F7
11.63
18.61
4.65
65.12
✓
✓
✓
Passed
F8
11.11
19.445
19.445
50
✓
✓
✓
Passed
F9
10
17.5
17.5
55
✓
-
-
Failed
F10
8.89
15.55
15.55
60
✓
-
-
Failed
F11
7.75
13.56
13.56
65.12
✓
-
-
Failed
F12
6.67
11.665
11.665
70
✓
✓
✓
Passed
F13
7.49
18.725
18.725
55
✓
-
-
Failed
F14
6.67
16.665
16.665
60
✓
✓
✓
Passed
F15
5.8
14.495
14.495
65.22
✓
✓
✓
Passed
F16
5
12.5
12.5
70
✓
-
-
Failed
NE formulation composition and physical screening studies, results of which demonstrated that the formulations prepared from the ratio of 4:1 passed the physical stability test.