Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China

Table 4

The relationship between p16 overexpression, HPV status, and Histological diagnosis.

Variable	p16-IHC			HPV DNA-PCR
	Positive	Negative		Positive	Negative
	Histological diagnosis
Squamous cell carcinoma
SCC NOS/conventional nonkeratinizing	13	161	0.862	12	162	0.318
Conventional keratinizing	66	1205	0	64	1207	0.242
Conventional exophytic keratinizing	2	12	0.169	2	6	0.127
Basaloid/papillary	0	2	0.732	0	2	0.737
Verrucous	0	1	0.809	0	1	0.813
Sarcomatoid	0	4	0.628	0	4	0.635
Undifferentiated carcinoma	0	2	0.732	0	2	0.737
Adenosquamous carcinoma	0	2	0.732	0	2	0.737
Differentiation
Well	24	443	0.0017	23	444	0.656
Moderate	20	798	0	19	799	0
Poor	37	148	0.000002	36	149	0
Lymphovascular invasion	56	559	0.0027	56	559	0
Perineural invasion	77	364	0.036	76	365	0
Extracapsular spread	10	234	0.068	8	236	0.122
Bone invasion	4	144	0	4	144	0.136
Pathological T category
T1	4	178	0.073	4	178	0.0456
T2	73	1140	0	70	1143	0.084
T3	2	59	0.394	2	59	0.471
T4	1	13	0	1	13	0.758
Pathological N category
N0	26	829	0.806	24	831	0
N1	25	397	0.02	24	398	0.679
N2a	19	100	0.00066	19	100	0
N2b	9	48	0.00052	9	48	0.00031
N2c	2	15	0.255	2	15	0.232
N3	0	0		0	0
Clinical stage
I/II	6	126	0.611	6	126	0.683
III/IV	75	1263	0.611	72	1266	0.683