TY - JOUR
A2 - Huang, Yan
AU - Yang, Lingyu
AU - Xian, Dehai
AU - Xiong, Xia
AU - Lai, Rui
AU - Song, Jing
AU - Zhong, Jianqiao
PY - 2018
DA - 2018/03/12
TI - Proanthocyanidins against Oxidative Stress: From Molecular Mechanisms to Clinical Applications
SP - 8584136
VL - 2018
AB - Proanthocyanidins (PCs) are naturally occurring polyphenolic compounds abundant in many vegetables, plant skins (rind/bark), seeds, flowers, fruits, and nuts. Numerous in vitro and in vivo studies have demonstrated myriad effects potentially beneficial to human health, such as antioxidation, anti-inflammation, immunomodulation, DNA repair, and antitumor activity. Accumulation of prooxidants such as reactive oxygen species (ROS) exceeding cellular antioxidant capacity results in oxidative stress (OS), which can damage macromolecules (DNA, lipids, and proteins), organelles (membranes and mitochondria), and whole tissues. OS is implicated in the pathogenesis and exacerbation of many cardiovascular, neurodegenerative, dermatological, and metabolic diseases, both through direct molecular damage and secondary activation of stress-associated signaling pathways. PCs are promising natural agents to safely prevent acute damage and control chronic diseases at relatively low cost. In this review, we summarize the molecules and signaling pathways involved in OS and the corresponding therapeutic mechanisms of PCs.
SN - 2314-6133
UR - https://doi.org/10.1155/2018/8584136
DO - 10.1155/2018/8584136
JF - BioMed Research International
PB - Hindawi
KW -
ER -