Research Article

Guava Leaf Extract Diminishes Hyperglycemia and Oxidative Stress, Prevents β-Cell Death, Inhibits Inflammation, and Regulates NF-kB Signaling Pathway in STZ Induced Diabetic Rats

Figure 4

(a) Effect of GLE on the pancreas histology of the control and experimental rats. (A) and (B) show normal pancreas histology of control (group 1) and GLE control (group 2), (C) pancreas histology of diabetic rats (group 3) showed infiltration and destroyed islet cells of pancreas as a result of which they were significantly reduced in size and number, (D) pancreas histology of treatment group (group 4) shows well-granulated and prominent hyperplasticity of islets, and (E) pancreas histology of GB group (group 5) shows well-granulated and prominent hyperplasticity of islets. (b) Immunoblot of NF-kB, TNF-α, and IL-6 protein samples (50 μg/lane) resolved on SDS-PAGE was probed with corresponding antibodies. Each lane was analyzed by densitometry and the expression in the control was considered as 100%. The column heights are the means ± SD of six determinants. Significantly different from control groups and significantly different from STZ alone treated groups .
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