100% inpatient stroke costs + 46% (proportion of patients with at least 4 weeks survival) stroke rehabilitation costs + 50% outpatient costs after stroke hospitalization + 50% oral anticoagulation costs
Costs per AF-patient receiving OAC, no stroke, alive
€678
100% oral anticoagulation costs
Costs per AF-patient receiving OAC, no stroke, death
€339
50% oral anticoagulation costs
Costs per AF-patient (not detected, no OAC), stroke, alive
€19,143
100% inpatient stroke costs 1,34 (cost increase due to untreated AF [33]) + 100% stroke rehabilitation costs + 100% outpatient costs after stroke + 100% costs ASA treatment
Costs per AF-patient (not detected, no OAC), fatal stroke
€13,808
100% inpatient stroke costs 1,34 (cost increase due to untreated AF [33]) + 46% (proportion of patients with at least 4 weeks survival) stroke rehabilitation costs + 50% outpatient costs after stroke + 50% costs ASA treatment
Costs per AF-patient (not detected, no OAC), no stroke, alive
-
No costs considered
Costs per AF-patient (not detected, no OAC), no stroke, death
100% inpatient stroke costs + 46% (proportion of patients with at least 4 weeks survival) stroke rehabilitation costs + 50% outpatient costs after stroke hospitalization + 50% costs ASA treatment
Cost per no AF-patient, no stroke, alive
-
No costs considered
Cost per no AF-patient, no stroke, death
-
No costs considered
Cost of Major bleeding
€1,995
Mean attributable costs due to major bleedings according to Bufe et al. 2009 [34] (ranging from €891 to €5,415)
For deceased patients, we assumed the costs for medications and outpatient treatment for a half year (50%). Annual unit costs used for calculations above: inpatient stroke costs €6,731 [35], stroke rehabilitation costs €6,822 [35], outpatient costs after stroke hospitalization €3,287 [35], oral anticoagulation costs €65.70 for Warfarin and €1,241.00 for Rivaroxaban [16] (weighted mean: €678.18), and costs of ASA treatment €14.60 [16]. ASA: acetylsalicylic acid; AF: atrial fibrillation; OAC: oral anticoagulation.
