Zoledronic Acid Regulates Autophagy and Induces Apoptosis in Colon Cancer Cell Line CT26

Figure 3

The cells were exposed to the 200 MZOL and at 12 h, 24 h, 36 h, and 48 h of exposure, the cell fractions were prepared and analyzed by 15% SDS-PAGE followed by Western blotting. (a and c) The level of c-caspase-3 in CT26 cells after being exposed to ZOL. (b and d) The level of p-p53 in CT26 cells after being exposed to ZOL. The data shown in C and D are the mean ± SD of the results of three independent experiments, respectively ( represents significant differences between the experimental and untreated control values).

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