Recovery following Thyroxine Treatment Withdrawal, but Not Propylthiouracil, Averts In Vivo and Ex Vivo Thyroxine-Provoked Cardiac Complications in Adult FVB/N Mice

Figure 2

Contractile profile of isolated right ventricular papillary muscles. (a) Mean active isometric developed force (), (b) their corresponding time to peak (TTP), and (c) 50% relaxation time (RT₅₀) at 4 Hz stimulation frequency and 2 mmol/L Ca²⁺. Basal; = 8, thyroxin (T4); = 8, propylthiouracil (PTU) + T4; = 10, recovery; = 9. significant change compared to basal, significant change compared to T4, and significant change compared to PTU + T4. One-way ANOVA followed by Tukey-Kramer’s post hoc multiple comparison test.

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