Research Article

Recovery following Thyroxine Treatment Withdrawal, but Not Propylthiouracil, Averts In Vivo and Ex Vivo Thyroxine-Provoked Cardiac Complications in Adult FVB/N Mice

Figure 1

Echocardiography analysis of mouse hearts. (a) Ejection fraction (EF), (b) fractional shortening (FS), (c) left ventricle (LV) mass, and (d) left ventricle (LV) mass/body weight (BW) ratio. Basal; = 19, thyroxin (T4); = 19, propylthiouracil (PTU) + T4; = 11, recovery; . significant change compared to basal, significant change compared to T4. EF and FS; one-way ANOVA followed by Tukey-Kramer’s post hoc multiple comparison test. LV mass and LV mass/BW ratio; Kruskal-Wallis test followed by Dunn’s post hoc multiple comparison test.