TY - JOUR A2 - Ogawa, Kazuma AU - Uccelli, Licia AU - Martini, Petra AU - Pasquali, Micol AU - Boschi, Alessandra PY - 2017 DA - 2017/08/30 TI - Monoclonal Antibodies Radiolabeling with Rhenium-188 for Radioimmunotherapy SP - 5923609 VL - 2017 AB - Rhenium-188, obtained from an alumina-based tungsten-188/rhenium-188 generator, is actually considered a useful candidate for labeling biomolecules such as antibodies, antibody fragments, peptides, and DNAs for radiotherapy. There is a widespread interest in the availability of labeling procedures that allow obtaining Re188-labeled radiopharmaceuticals for various therapeutic applications, in particular for the rhenium attachment to tumor-specific monoclonal antibodies (Mo)Abs for immunotherapy. Different approaches have been developed in order to obtain Re188-radioimmunoconjugates in high radiochemical purity starting from the generator eluted Re188ReO4-. The aim of this paper is to provide a short overview on Re188-labeled (Mo)Abs, focusing in particular on the radiolabeling methods, quality control of radioimmunoconjugates, and their in vitro stability for radioimmunotherapy (RIT), with particular reference to the most important contributions published in literature in this topic. SN - 2314-6133 UR - https://doi.org/10.1155/2017/5923609 DO - 10.1155/2017/5923609 JF - BioMed Research International PB - Hindawi KW - ER -