New Insights into the Epigenetics of Hepatocellular Carcinoma

Table 2

Role of different miRNAs in HCC.

miRNA	Function of miRNA	Gene target involved	Reference
miRNA-221	Oncogenic	DDIT4, CDKN1C/p57, CDKN1B/p27	[39]
miRNA-125b	Tumor suppressor	LIN28B	[40]
miRNA-214	Tumor suppressor	c-Myc, TCF-1, Cyclin D1	[41]
let-7 family	Tumor suppressor	c-Myc, STAT3	[42]
miRNA-26	Tumor suppressor	MMP2, cyclin D1, Mcl-1, Bcl-2	[43]
miRNA-122	Tumor suppressor	ADAM10, igF1R, SRF, Cyclin G1, Wnt1, AKT3, Bcl-w	[44, 45]
miRNA-96	Oncogenic	ephrinA5	[46]
miRNA-101	Tumor suppressor	Mcl-1	[47]
miRNA-186	Tumor suppressor	Yes-associated protein 1	[48]
miRNA-29	Tumor suppressor	Mcl-2, Bcl-2	[49]
miRNA-125b	Tumor suppressor	ILL- 6R, Bcl-w, Mcl-1, Bcl-2	[50]
miRNA-129-2	Tumor suppressor	High mobility group box 1	[51]
miRNA-193a-3p	Oncogenic	SRSF2	[52]
miRNA-133b	Tumor suppressor	SIRT1	[53]
miRNA-199a-3p	Tumor suppressor	c-Met, mTOR	[54]
miRNA-199a-5p	Tumor suppressor	ATG7	[55]
miRNA-155-3p	Oncogenic	FBXW7	[56]
miRNA-222	Oncogenic	PPP2R2A, p27	[57]
miRNA-21	Oncogenic	PTEN, kinase 3	[58]
miRNA-449a	Tumor suppressor	ADAM10	[59]
miRNA-139	Tumor suppressor	ROCK2, Rho Kinase 2	[60]
miRNA-125b	Tumor suppressor	LIN28B, PDZ binding motif, Sirtuin 7	[40, 50, 60]
miRNA-182	Oncogenic	ephrinA5	[46]
miRNA-125a	Tumor suppressor	VEGF-A, MMP11	[61]
miRNA-1180	Increase apoptotic resistance to HCC	Through activation of NF-κB pathway	[62]
miRNA-200 family	Tumor suppressor	ZEB2, ZEB1	[63]
miRNA-212	Tumor suppressor	FOXA1	[64, 65]
miRNA-497	Tumor suppressor	YAP1	[66]
miRNA-519d	Metastasis	PTEN	[67]
miRNA-106b	Apoptosis	Bim	[68]