New Insights into the Epigenetics of Hepatocellular Carcinoma

Figure 3

Role of miRNA, mRNA, and lncRNA in regulation of apoptosis, migration, metastasis, tumorigenicity, cell cycle, invasion, and cell proliferation. PCNA (Proliferating Cell Nuclear Antigen) regulation is related to PCNA-AS1 effects and this event involves the formation of RNA hybridization that increases PCNA mRNA stability. (b) H19 affects let-7 mediated genes involved in promotion of metastasis specifically IGF2BP1 (insulin-like growth factor 2 mRNA-binding protein). (c) Autophagy genes, for example, p62, ATG7 (autophagy-related gene 7), and ULK1 (unccoordinated-51- (unc-51-) like kinase 1), are regulated by PTENP1 that is targeted by miR-17 family. (d) The stability of IL-11 (interleukin-11) mRNA is increased by lncRNA-ATB. (e) miR-125b negatively targeted by HOTTIP. (f) The regulation of MALAT1 is regulated in the nucleus after being binded with miR-9 following AGO2-dependent path. (g) The activity and expression of miR-372 are repressed after getting binded with HULC. Target mRNA of miR-372, that is, Prkacb (cAMP-dependent protein kinase catalytic subunit beta), level is increased in response to mi-372 reduction [127].