Research Article
CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention
Table 4
Cox’s proportional hazard regression model for multivariate analysis.
| Variables | Disease-free survival | Overall survival | | Exp (B)/HR | 95% CI | | Exp (B)/HR | 95% CI | Lower | Upper | Lower | Upper |
| Gender (male) | 0.088 | 1.679 | 0.926 | 3.045 | 0.265 | 1.400 | 0.775 | 2.529 | Age (≥66) | 0.180 | 1.412 | 0.852 | 2.339 | 0.102 | 1.539 | 0.918 | 2.580 | Smoking (never) | 0.088 | 0.623 | 0.362 | 1.074 | 0.082 | 0.608 | 0.347 | 1.064 | Pathological type | | | | | | | | | AD | 0.014 | 1.000 | | | 0.001 | 1.000 | | | SQ | 0.137 | 0.624 | 0.335 | 1.162 | 0.230 | 0.674 | 0.354 | 1.284 | LA | 0.050 | 2.018 | 0.999 | 4.078 | 0.005 | 2.834 | 1.371 | 5.859 | Others | 0.642 | 0.775 | 0.264 | 2.273 | 0.871 | 1.096 | 0.363 | 3.306 | Differentiation | | | | | | | | | Poor | 0.139 | 1.000 | | | 0.028 | 1.000 | | | Moderate | 0.256 | 0.753 | 0.462 | 1.228 | 0.155 | 0.700 | 0.428 | 1.144 | Well | 0.055 | 0.412 | 0.167 | 1.018 | 0.009 | 0.255 | 0.091 | 0.712 | T stage | | | | | | | | | T1 | 0.002 | 1.000 | | | 0.001 | 1.000 | | | T2 | 0.000 | 4.051 | 1.858 | 8.835 | 0.000 | 4.320 | 1.978 | 9.435 | T3 | 0.040 | 2.422 | 1.040 | 5.640 | 0.007 | 3.171 | 1.379 | 7.290 | T4 | 0.003 | 5.524 | 1.783 | 17.109 | 0.001 | 7.859 | 2.425 | 25.467 | N stage | | | | | | | | | N0 | 0.161 | 1.000 | | | 0.031 | 1.000 | | | N1 | 0.572 | 0.763 | 0.299 | 1.948 | 0.932 | 1.043 | 0.398 | 2.734 | N2 | 0.170 | 1.659 | 0.805 | 3.418 | 0.014 | 2.613 | 1.212 | 5.630 | N3 | 0.313 | 2.236 | 0.469 | 10.667 | 0.215 | 2.681 | 0.565 | 12.719 | M stage (M1) | 0.001 | 5.499 | 2.079 | 14.543 | 0.002 | 4.708 | 1.746 | 12.689 | Clinical | | | | | | | | | I | 0.049 | 1.000 | | | 0.115 | 1.000 | | | II | 0.005 | 6.274 | 1.725 | 22.816 | 0.018 | 4.878 | 1.316 | 18.076 | IIIa | 0.089 | 2.312 | 0.881 | 6.064 | 0.302 | 1.701 | 0.621 | 4.658 | IIIb | 0.219 | 2.413 | 0.593 | 9.824 | 0.522 | 1.595 | 0.383 | 6.647 | G199T (mutant) | 0.491 | 1.176 | 0.742 | 1.863 | 0.478 | 1.185 | 0.741 | 1.896 | C432G (mutant) | 0.536 | 1.200 | 0.674 | 2.138 | 0.665 | 1.137 | 0.637 | 2.30 |
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or linearly dependent covariates clinical stage V = M stage 1.
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