Systematic Analysis of the Cytokine and Anhedonia Response to Peripheral Lipopolysaccharide Administration in Rats

Figure 3

Peripheral LPS administration transiently increases serum levels of corticosterone, leptin, cytokines, and chemokines. Time curves of corticosterone (CORT), chemokine (C-X-C motif) ligand 1 (CXCL1), interferon-γ (IFN-γ), interleukin- (IL-) 1β, IL-6, IL-10, leptin, monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), and tumor necrosis factor-α (TNF-α) quantified in serum at 0 h, 1 h, 2 h, 6 h, 24 h, 48 h, 72 h, and 96 h after LPS injection (0.63 mg/kg, i.p.). The detection limit of each analyte is indicated by a tick on the -axis of its individual graph. Detection limits that fall below the lowest value on the -axis are not presented. Graphs are plotted as mean ± SEM ( per group). Data were analyzed by rmANOVA followed by independent samples -test. , , , and compared to vehicle.