Research Article
Subclinical Hypothyroidism in PCOS: Impact on Presentation, Insulin Resistance, and Cardiovascular Risk
Table 1
Characteristics of study population.
| | Variable | PCOS ()
(mean ± SD) | Control ()
(mean ± SD) | value |
| | Age (years) | 27.4 ± 5.4 | 23.3 ± 4.1 | NS | | BMI (Kg/m2) | 31.2 ± 8.3 | 29.2 ± 5.1 | NS | | Hypertension (%) | 18 () | 5 () | <0.001 | | Hirsutism (%) | 76 () | 13 () | <0.001 | | Ferriman and Gallwey score | 19.31 ± 9.7 | 8.32 ± 4.8 | <0.001 | | LH (mIU/mL) | 12.72 ± 4.9 | 10.19 ± 4.1 | <0.001 | | FSH (mIU/mL) | 5.01 ± 2.1 | 4.26 ± 2.1 | 0.01 | | LH/FSH ratio | 2.7 ± 0.8 | 1.05 ± 1.02 | <0.01 | | Free T3 (pg/mL) | 2.61 ± 1.4 | 3.48 ± 0.8 | 0.03 | | Free T4 (ng/dL) | 1.17 ± 1.2 | 1.21 ± 2.9 | NS | | TSH (mIU/mL) | 5.11 ± 22.7 | 2.9 ± 3.2 | <0.001 | | Anti-TPO ab (IU/mL) | 76.23 ± 23.4 | 20.14 ± 12.4 | <0.001 | | Free testosterone (pg/mL) | 21.13 ± 9.2 | 12.4 ± 6.1 | <0.001 | | Estradiol (pg/mL) | 62.21 ± 31.6 | 67.34 ± 45.21 | NS | | Progesterone (ng/mL) | 2.4 ± 1.8 | 9.1 ± 5.2 | <0.001 | | HOMA-IR | 3.6 ± 1.7 | 1.7 ± 1.0 | <0.001 | | Hypoechoic USG (%) | 34 () | 7 () | <0.01 | | Total cholesterol (mg/dL) | 232 ± 31.4 | 172 ± 26.7 | 0.02 | | Triglycerides (mg/dL) | 124 ± 21.3 | 86.9 ± 12.4 | 0.01 | | LDL Chol. (mg/dL) | 143 ± 19.7 | 112 ± 26.1 | 0.01 | | HDL Chol. (mg/dL) | 39.4 ± 17.3 | 56.9 ± 6.7 | 0.01 |
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; statistically significant.
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